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The late\u2010stage functionalization of the parent methylene\u2010bridged [6]cycloparaphenylene ([6]MCPP) provided an easily accessible alkyne\u2010functionalized nanobelt in a single reaction step. The alkyne\u2010substituted [6]MCPP was subjected to Cu\u2010catalyzed azide\u2013alkyne cycloaddition by using a dye\u2010attached azide to obtain a water\u2010soluble aromatic nanobelt. Cell\u2010imaging experiments on the synthesized nanobelt in HeLa cells revealed stop\u2010and\u2010go cellular uptake dynamics. Similar experiments with control molecules and theoretical studies indicated that the unique dynamics of the nanobelt was derived from the belt\u2010shaped structure.<\/jats:p>","DOI":"10.1002\/anie.202414645","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T04:29:21Z","timestamp":1727670561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Water\u2010Soluble Aromatic Nanobelt with Unique Cellular Internalization"],"prefix":"10.1002","volume":"64","author":[{"given":"Konstantin","family":"G\u00fcnther","sequence":"first","affiliation":[{"name":"Department of Chemistry Graduate School of Science Nagoya University, Chikusa  Nagoya 464-8602 Japan"},{"name":"Department of Chemistry Humboldt-Universit\u00e4t zu Berlin  Brook-Taylor-Stra\u00dfe 2 12489 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideya","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Chemistry Graduate School of Science Nagoya University, Chikusa  Nagoya 464-8602 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Shudo","sequence":"additional","affiliation":[{"name":"Department of Chemistry Graduate School of Science Nagoya University, Chikusa  Nagoya 464-8602 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Graduate School of Science Nagoya University, Chikusa  Nagoya 464-8602 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reika","family":"Isoda","sequence":"additional","affiliation":[{"name":"Institute of Transformative Bio-Molecules (WPI-ITbM) Nagoya University, Chikusa  Nagoya 464-8602 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Institute of Transformative Bio-Molecules (WPI-ITbM) Nagoya University, Chikusa  Nagoya 464-8602 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Graduate School of Science Nagoya University, Chikusa  Nagoya 464-8602 Japan"},{"name":"Institute of Transformative Bio-Molecules (WPI-ITbM) Nagoya University, Chikusa  Nagoya 464-8602 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuma","family":"Amaike","sequence":"additional","affiliation":[{"name":"Molecule Creation Laboratory RIKEN Cluster for Pioneering Research, RIKEN  Wako Saitama 351-0198 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5227-7894","authenticated-orcid":false,"given":"Kenichiro","family":"Itami","sequence":"additional","affiliation":[{"name":"Institute of Transformative Bio-Molecules (WPI-ITbM) Nagoya University, Chikusa  Nagoya 464-8602 Japan"},{"name":"Molecule Creation Laboratory RIKEN Cluster for Pioneering Research, RIKEN  Wako Saitama 351-0198 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"e_1_2_3_1_1","unstructured":"\u00a0"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00366G"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201508384"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-021-00671-9"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/prechem.3c00083"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja807126u"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200902617"},{"key":"e_1_2_3_8_1","unstructured":"\u00a0"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2ob25199j"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5CS00143A"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/C2SC20878D"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam8158"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b06842"},{"key":"e_1_2_3_14_1","unstructured":"\u00a0"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-020-00627-5"},{"key":"e_1_2_3_16_2","first-page":"1","author":"Segawa Y.","year":"2022","journal-title":"Nat. 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