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Here we report Ni\u2010catalyzed reductive hydrolysis of nitriles to alcohols in the presence of molecular hydrogen. This conversion likely occurs in a domino reaction sequence that first involves the hydrogenation of nitrile to primary imine, then the hydrolysis of imine, and subsequent deamination to the aldehyde, which is finally hydrogenated to the desired alcohol. Crucial for this reductive hydrolysis process is the commercially available triphos\u2010ligated Ni\u2010complex that enables highly efficient and selective transformation of aromatic, heterocyclic, and aliphatic nitriles including fatty nitriles to prepare functionalized primary alcohols. Further, the synthetic applicability of this Ni\u2010based protocol is presented for the selective conversion of nitrile to alcoholic group in structurally diverse and complex drug molecules as well as agrochemicals. The resulting products, alcohols are indispensable chemicals commonly used in organic synthesis and life sciences as well as material and energy technologies.<\/jats:p>","DOI":"10.1002\/anie.202414689","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T04:19:52Z","timestamp":1733458792000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nickel\u2010Catalyzed Reductive Hydrolysis of Nitriles to Alcohols"],"prefix":"10.1002","volume":"64","author":[{"given":"Chakreshwara","family":"Kuloor","sequence":"first","affiliation":[{"name":"Leibniz-Institut f\u00fcr Katalyse  Albert-Einstein-Stra\u00dfe 29a 18059 Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Akash","sequence":"additional","affiliation":[{"name":"Leibniz-Institut f\u00fcr Katalyse  Albert-Einstein-Stra\u00dfe 29a 18059 Rostock 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