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Typically, anabolism of intracellular substance in cell factory requires the consumption of sufficient reduced nicotinamide adenine dinucleotide \/nicotinamide adenine dinucleotide phosphate NAD(P)H and adenosine triphosphate ATP. However, it is of great challenge to modify the natural limited anabolism and to increase the insufficient level of NAD(P)H and ATP to optimum concentrations without causing metabolic disorder. Inspired by the natural photosynthesis process in which NAD(P)H and ATP can both be produced through the coupled electron\u2010proton transfer processes driven by sunlight, herein we designed a light\u2010driven bionic system composed of three modules including photo\u2010induced electron module, electron transfer channel module and proton gradient module. The proposed strategy of light\u2010driven bionic system enables for achieving simultaneous and controllable supplies of NAD(P)H and ATP, thus facilitating both highly efficient CO<jats:sub>2<\/jats:sub> fixation and biomanufacturing. The proposed light\u2010driven bionic system design strategy in this work might pave new sustainable ways for reducing power and energy regeneration to optimize microbial metabolism, offering intriguing alternatives for CO<jats:sub>2<\/jats:sub> emission mitigation and high\u2010value chemical biomanufacturing.<\/jats:p>","DOI":"10.1002\/anie.202414981","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T22:36:07Z","timestamp":1736807767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A photosynthesis\u2010derived bionic system for sustainable biosynthesis"],"prefix":"10.1002","volume":"64","author":[{"given":"Na","family":"Chen","sequence":"first","affiliation":[{"name":"Renmin Hospital of Wuhan University College of Chemistry and Molecular Sciences Institute of Molecular Medicine School of Microelectronics Wuhan University  Wuhan 430072 P. R. 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