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The transition\u2010metal catalyzed stereoselective hydrogenation of olefins and ketones typically proceeds under different reaction conditions and\/or uses a different reductant. As a result, these two types of hydrogenations can normally not be performed in the same pot. Herein, the stereocontrolled hydrogenation of enones to saturated alcohols is described, enabled by orthogonal dual iridium catalysis, using molecular hydrogen for both reductions. In this one\u2010pot procedure, N,P\u2010iridium catalysts (hydrogenation active towards olefins) and NHC,P\u2010iridium catalysts (hydrogenation active towards ketones) operated independently of one another allowing the construction of two contiguous stereogenic centers up to 99\u2009%\n                    <jats:italic>ee<\/jats:italic>\n                    , 99\/1 d.r. Ultimately, by simple selection of the chirality of either ligands, the enone could be efficiently reduced to all four stereoisomers of the saturated alcohol in equally high stereopurity. This degree of stereocontrol for the synthesis of different stereoisomers by dual transition\u2010metal catalyzed hydrogenation was previously not attained. The generality in substituted enones (alkyl, aryl, heteroaryl) demonstrate the wide applicability of this concept.\n                  <\/jats:p>","DOI":"10.1002\/anie.202415171","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T09:51:17Z","timestamp":1727257877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Stereocontrolled Hydrogenation of Conjugated Enones to Alcohols via Dual Iridium\u2010Catalysis"],"prefix":"10.1002","volume":"64","author":[{"given":"Jia","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry Stockholm University  10691 Stockholm Sweden"},{"name":"The Marine Biomedical Research Institute School of Ocean and Tropical Medicine Guangdong Medical University  Zhanjiang 524023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7788-3866","authenticated-orcid":false,"given":"Bram B. 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