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Current therapeutic strategies for managing MI\u2010induced VAs, such as left stellate ganglion resection and ablation, are suboptimal, highlighting the need to explore safer and more effective intervention strategies. Herein, we rationally designed two supramolecular sonosensitizers\n                    <jats:bold>RuA<\/jats:bold>\n                    and\n                    <jats:bold>RuB<\/jats:bold>\n                    , engineered through acceptor modification to generate moderate reactive oxygen species (ROS) to modulate VAs. Both\n                    <jats:bold>RuA<\/jats:bold>\n                    and\n                    <jats:bold>RuB<\/jats:bold>\n                    demonstrated high ultrasound (US)\u2010activated ROS production efficiency, with singlet oxygen (\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) quantum yield (\u03a6\n                    <jats:sub>\u0394<\/jats:sub>\n                    ) of 0.70 and 0.88, respectively, surpassing ligand\n                    <jats:bold>IR1105<\/jats:bold>\n                    and the conventional sonosensitizer ICG (\u03a6\n                    <jats:sub>\u0394<\/jats:sub>\n                    =0.40). In vitro,\n                    <jats:bold>RuB<\/jats:bold>\n                    , at a modest concentration and under US intensity notably boosts pro\u2010survival autophagy in microglia BV2\u2005cell. To improve in vivo stability and biocompatibility,\n                    <jats:bold>RuB<\/jats:bold>\n                    was further encapsulated into DSPE\u2010PEG\n                    <jats:sub>5000<\/jats:sub>\n                    to prepare\n                    <jats:bold>RuB<\/jats:bold>\n                    nanoparticles (\n                    <jats:bold>RuB<\/jats:bold>\n                    NPs). In vivo studies after microinjection of\n                    <jats:bold>RuB<\/jats:bold>\n                    NPs into the paraventricular nucleus (PVN) and subsequent US exposure, demonstrated that\n                    <jats:bold>RuB<\/jats:bold>\n                    NPs\u2010mediated US modulation effectively suppresses sympathetic nervous activity (SNA) and inflammatory responses, thereby preventing VAs. Importantly, no tissue injury was observed post\n                    <jats:bold>RuB<\/jats:bold>\n                    NPs\u2010mediated US modulation. This work pioneers the design of long\u2010wave emission supramolecular sonosensitizers, offering new insights into regulating cardiovascular diseases.\n                  <\/jats:p>","DOI":"10.1002\/anie.202415802","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T09:18:45Z","timestamp":1726651125000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["An Ultrasound\u2010Activated Supramolecular Modulator Enhancing Autophagy to Prevent Ventricular Arrhythmias Post\u2010Myocardial Infarction"],"prefix":"10.1002","volume":"64","author":[{"given":"Yida","family":"Pang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and Health College of Chemistry Central China Normal University  Wuhan 430079 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and Health College of Chemistry Central China Normal University  Wuhan 430079 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Cardiac Autonomic Nervous System Research Center of Wuhan Univesity Cardiovascular Research Institute Wuhan University  Wuhan 430072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Cardiac Autonomic Nervous System Research Center of Wuhan Univesity Cardiovascular Research Institute Wuhan University  Wuhan 430072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Sharma","sequence":"additional","affiliation":[{"name":"Amity School of Chemical Sciences Amity University Punjab Sector 82\u2005A, Mohali  Punjab 140306 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and Health College of Chemistry Central China Normal University  Wuhan 430079 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Cardiac Autonomic Nervous System Research Center of Wuhan Univesity Cardiovascular Research Institute Wuhan University  Wuhan 430072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junrong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and Health College of Chemistry Central China Normal University  Wuhan 430079 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Wuhan University of Technology  Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6519-7436","authenticated-orcid":false,"given":"Yao","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and Health College of Chemistry Central China Normal University  Wuhan 430079 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61413-5"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-119-12-199312150-00006"},{"key":"e_1_2_7_4_1","unstructured":"\u00a0"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000810"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101501"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27637-2"},{"key":"e_1_2_7_8_1","unstructured":"\u00a0"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101186"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.029053","volume":"12","author":"Wang M.","year":"2023","journal-title":"J. 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