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The construction of unique tetrasubstituted allene scaffolds with precise control of continuous central and axial chirality remains yet to be developed. Here, we report a remote enantioselective \u03f5\u2010alkylation of yne\u2010propargylic acetates with enals enabled by NHC and copper cooperative catalysis, leading to a series of tetrasubstituted allenes with excellent enantioselectivities (up to &gt;99\u2009% ee) and diastereoselectivities (up to &gt;95\u2009:\u20095 dr). This method features high regioselectivity and simultaneous control of axial and central chirality. Mechanistic studies suggest a cooperative activation mode and synergistic control of distal chirality created from the copper ethynylallenylidenes.<\/jats:p>","DOI":"10.1002\/anie.202416089","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T12:41:07Z","timestamp":1729168867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Remote Enantioselective \u03f5\u2010Alkylation of Copper Ethynylallenylidenes: Precise Control of Central and Axial Chirality"],"prefix":"10.1002","volume":"64","author":[{"given":"Yu\u2010Hua","family":"Wen","sequence":"first","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of China  Hefei 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghao","family":"Liu","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of China  Hefei 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of China  Hefei 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian\u2010Wei","family":"Gong","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of China  Hefei 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Li","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of China  Hefei 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Institutes of Physical Science and Information Technology Anhui University  Hefei 230601 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6099-827X","authenticated-orcid":false,"given":"Liu\u2010Zhu","family":"Gong","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of China  Hefei 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","unstructured":"Modern Allene Chemistry(Ed.: N. 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