{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:31:27Z","timestamp":1785007887010,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22125405"],"award-info":[{"award-number":["22125405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22404146"],"award-info":[{"award-number":["22404146"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ24B050002"],"award-info":[{"award-number":["LQ24B050002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>High\u2010altitude hypoxic brain injury (HHBI) is a kind of acute mountain sickness and the survival rate of patients with HHBI can be improved only if it is detected and treated at the early stage. However, limited by speediness and accuracy, it is still very difficult for most of current approaches to realize the early detection of HHBI. We propose herein a novel strategy for this goal based on spatiotemporal changes in the brain oxygen level. As revealed by in vivo electrochemistry, the characteristic changes of brain oxygen level under the high\u2010altitude exposure are directly associated with the brain hypoxia status. Given brain hypoxia is the main pathogenesis of HHBI, the degree of HHBI can be diagnosed by the variation of brain oxygen, making the early detection of HHBI feasible. In addition, the risk of HHBI for mouse exposed to high\u2010altitude hypoxia environments can be also prognosed days in advance.<\/jats:p>","DOI":"10.1002\/anie.202416395","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T03:19:51Z","timestamp":1730776791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Early Detection of High\u2010Altitude Hypoxic Brain Injury by In Vivo Electrochemistry"],"prefix":"10.1002","volume":"64","author":[{"given":"Xinru","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Analytical Chemistry Department of Chemistry Zhejiang University  310058 Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Analytical Chemistry Department of Chemistry Zhejiang University  310058 Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuo","family":"Dong","sequence":"additional","affiliation":[{"name":"Institute of Analytical Chemistry Department of Chemistry Zhejiang University  310058 Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Analytical Chemistry Department of Chemistry Zhejiang University  310058 Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Cao","sequence":"additional","affiliation":[{"name":"Institute of Analytical Chemistry Department of Chemistry Zhejiang University  310058 Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Analytical Chemistry Department of Chemistry Zhejiang University  310058 Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Gao","sequence":"additional","affiliation":[{"name":"General Surgery Department Children's Hospital Zhejiang University School of Medicine National Clinical Research Center for Child Health  310052 Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0115-2279","authenticated-orcid":false,"given":"Bin","family":"Su","sequence":"additional","affiliation":[{"name":"Institute of Analytical Chemistry Department of Chemistry Zhejiang University  310058 Hangzhou China"},{"name":"General Surgery Department Children's Hospital Zhejiang University School of Medicine National Clinical Research Center for Child Health  310052 Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"e_1_2_3_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26116-y"},{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13408"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2104829"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70014-6"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7863"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.03.035"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1408"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/456715a"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.04.013"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz2078"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adh7726"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay9040"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/HTR.0b013e3181e5477c"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn730"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-015-1579-5"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.752465"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202111630"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202111630"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0152-y"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00248"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2038"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.09.040"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1872-2040(19)61191-6"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c09011"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201710863"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201710863"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202303053"},{"key":"e_1_2_3_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202303053"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.156"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03497-0"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00543"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar200196h"},{"key":"e_1_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.367"},{"key":"e_1_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202010675"},{"key":"e_1_2_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202010675"},{"key":"e_1_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/elan.202100215"},{"key":"e_1_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0384-5"},{"key":"e_1_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201509241"},{"key":"e_1_2_3_34_2","first-page":"2098","volume":"128","year":"2015","journal-title":"Angew. Chem."},{"key":"e_1_2_3_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b05658"},{"key":"e_1_2_3_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac960239r"},{"key":"e_1_2_3_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202204468"},{"key":"e_1_2_3_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00484-022-02298-y"},{"key":"e_1_2_3_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0603-677"},{"key":"e_1_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2014.0637"},{"key":"e_1_2_3_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00525-1"},{"key":"e_1_2_3_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax9238"},{"key":"e_1_2_3_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0716-8"},{"key":"e_1_2_3_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.01.005"},{"key":"e_1_2_3_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.08.001"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202416395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202416395","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202416395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T16:50:45Z","timestamp":1777740645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202416395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,18]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,1,21]]}},"alternative-id":["10.1002\/anie.202416395"],"URL":"https:\/\/doi.org\/10.1002\/anie.202416395","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,18]]},"assertion":[{"value":"2024-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202416395"}}