{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:42:20Z","timestamp":1792806140321,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Francisella tularensis<\/jats:italic>\n                    , a category A bioterrorism agent, causes tularemia in many animal species.\n                    <jats:italic>F. tularensis<\/jats:italic>\n                    subspecies\n                    <jats:italic>tularensis<\/jats:italic>\n                    (type A) and\n                    <jats:italic>holarctica<\/jats:italic>\n                    (type B) are mainly responsible for human tularemia. The high mortality rate of 30\u201360\u2009% caused by\n                    <jats:italic>F. tularensis<\/jats:italic>\n                    subspecies\n                    <jats:italic>tularensis<\/jats:italic>\n                    if left untreated and the aerosol dispersal renders this pathogen a dangerous bioagent. While a live attenuated vaccine strain (LVS) of\n                    <jats:italic>F. tularensis<\/jats:italic>\n                    type B does not provide sufficient protection against all forms of tularemia infections, a significant level of protection against\n                    <jats:italic>F. tularensis<\/jats:italic>\n                    has been observed for both passive and active immunization of mice with isolated\n                    <jats:italic>O<\/jats:italic>\n                    \u2010antigen capsular polysaccharide. Well\u2010defined, synthetic oligosaccharides offer an alternative approach towards the development of glycoconjugate vaccines. To identify diagnostics and therapeutics leads against tularemia, a collection of\n                    <jats:italic>F. tularensis<\/jats:italic>\n                    strain 15\n                    <jats:italic>O<\/jats:italic>\n                    \u2010antigen capsular polysaccharide epitopes were chemically synthesized. Glycan microarrays containing synthetic glycans were used to analyze the sera of tularemia\u2010infected and non\u2010infected animals and revealed the presence of IgG antibodies against the glycans. Two disaccharide (\n                    <jats:bold>13<\/jats:bold>\n                    and\n                    <jats:bold>18<\/jats:bold>\n                    ), both bearing a unique formamido moiety, were identified as minimal glycan epitopes for antibody binding. These epitopes are the starting point for the development of diagnostics and therapeutics against tularemia.\n                  <\/jats:p>","DOI":"10.1002\/anie.202416432","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T10:43:50Z","timestamp":1729161830000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Synthetic Oligosaccharide Resembling\n                    <i>Francisella tularensis<\/i>\n                    Strain 15\n                    <i>O<\/i>\n                    \u2010Antigen Capsular Polysaccharide as a Lead for Tularemia Diagnostics and Therapeutics"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4220-3079","authenticated-orcid":false,"given":"Kabita","family":"Pradhan","sequence":"first","affiliation":[{"name":"Department of Biomolecular Systems Max Planck Institute of Colloids and Interfaces  Am M\u00fchlenberg 1 14476 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