{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:21:01Z","timestamp":1788369661201,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22261051"],"award-info":[{"award-number":["22261051"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Conversion of quinoline C\u2212H bonds into C\u2212C bonds is essential for obtaining the enormous array of derivatives required for pharmaceutical and agrochemical development. Despite over a century of synthetic efforts, direct alkylation and alkenylation at C3\u2212H positions in a wide array of quinoline precursors remain predominantly challenging and elusive. This report outlines the first successful quinoline C3\u2212H alkylation and alkenylation reactions, exhibiting exceptional regio\u2010 and stereoselectivity, all achieved under redox\u2010neutral and transition\u2010metal\u2010free conditions. The method involves a three\u2010step, one\u2010pot or two\u2010pot sequence, including 1,4\u2010dearomative addition, functionalization at C3, and elimination or transalkylation to produce 3\u2010alkylated\/alkenylated quinolines. The presence of a carbonyl group in these products allows for further synthetic manipulations, enabling the production of cyanides, amides, amines, and simple alkyl derivatives.<\/jats:p>","DOI":"10.1002\/anie.202416451","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T08:53:39Z","timestamp":1726736019000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Direct C3\u2212H Alkylation and Alkenylation of Quinolines with Enones"],"prefix":"10.1002","volume":"64","author":[{"given":"Liqing","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources College of Chemistry Xinjiang University  No.\u2005777, Hua Rui Street, Shui Mo Gou District 830046 Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key 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