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Herein, we present the radiosynthesis and application of [\n                    <jats:sup>18<\/jats:sup>\n                    F]trifluoroiodomethane \u2013 the first reagent for broad scope radical [\n                    <jats:sup>18<\/jats:sup>\n                    F]trifluoromethylation chemistry in high molar activity. CF\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>18<\/jats:sup>\n                    FI can be prepared from [\n                    <jats:sup>18<\/jats:sup>\n                    F]fluoroform with 67\u00b15\u2009% AY and &gt;99\u2009% RCP. Its synthetic utility is demonstrated by the radiosynthesis of previously unprecedented\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010labeled \u03b1\u2010trifluoromethyl ketones and\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010labeled trifluoromethyl sulfides, important motifs that are present in a range of bioactive compounds. Both protocols are Ru\u2010 and photo\u2010mediated and proceed under mild reaction conditions. They show good functional group tolerance evidenced by the respective reaction scopes and make use of easily obtainable starting materials. The products can be isolated in 8.3\u201311.1 GBq\/\u03bcmol (starting from ca. 5\u00a0GBq [\n                    <jats:sup>18<\/jats:sup>\n                    F]fluoride). The applicability to PET tracer synthesis is shown by the radiolabeling of bioactive compounds, such as derivatives of probenecid and febuxostat. In a broader context, this work opens the door to the utilization of radical [\n                    <jats:sup>18<\/jats:sup>\n                    F]trifluoromethylation chemistry for the radiolabeling of PET tracers in high molar activity.\n                  <\/jats:p>","DOI":"10.1002\/anie.202416901","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T21:59:03Z","timestamp":1727733543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["[\n                    <sup>18<\/sup>\n                    F]Trifluoroiodomethane \u2013 Enabling Photoredox\u2010mediated Radical [\n                    <sup>18<\/sup>\n                    F]Trifluoromethylation for Positron Emission Tomography"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2534-274X","authenticated-orcid":false,"given":"Lukas","family":"Veth","sequence":"first","affiliation":[{"name":"Dept. 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