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While electrochemical methods enhance safety and may avoid the use of noble metals, these processes suffer from low yields due to limited current density and\/or low selectivity. Here, we design an electrothermal process to conduct aerobic oxidation of methane to methanol at room temperature using phosphotungstic acid (PTA) as a redox mediator. When electrochemically reduced, PTA activates methane with O<jats:sub>2<\/jats:sub> to produce methanol selectively. The optimum productivity reaches 29.45 \n with approximately 20.3\u2009% overall electron yield. Under continuous operation, we achieved 19.90 \n catalytic activity, over 74.3\u2009% methanol selectivity, and 10\u2005hours durability. This approach leverages reduced PTA to initiate thermal catalysis in solution phase, addressing slow methane oxidation kinetics and preventing overoxidations on electrode surfaces. The current density towards methanol production increased over 40 times compared with direct electrochemical processes. The in situ generated hydroxyl radical, from the reaction of reduced PTA and oxygen, plays an important role in the methane conversion. This study demonstrates reduced polyoxotungstate as a viable platform to integrate thermo\u2010 and electrochemical methane oxidation at ambient conditions.<\/jats:p>","DOI":"10.1002\/anie.202417251","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T07:32:37Z","timestamp":1729927957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Electrothermal Conversion of Methane to Methanol at Room Temperature with Phosphotungstic Acid"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9569-550X","authenticated-orcid":false,"given":"Jinquan","family":"Chang","sequence":"first","affiliation":[{"name":"Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University Binhai New City  Fuzhou 350207 China"},{"name":"Department of Chemical and Biomolecular Engineering National University of Singapore 4 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