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Of particular interest is phototheranostic agent with emission in the second near\u2010infrared (NIR\u2010II) window. Nevertheless, the practical uses of those conventional NIR\u2010II agents are severely impeded by their unsatisfactory features including insufficient stability, low synthetic yield, to be extended absorption\/ emission wavelengths, and inefficient phototheranostic outcomes. Developing exceptional phototheranostic agents is thus highly desirable yet remains formidably challenging. Herein, we synthesized two novel\n                    <jats:italic>N<\/jats:italic>\n                    \u2010heteroacenes\u2010based NIR\u2010II luminogens, namely 2TT\u2010PPT and 4TT\u2010PBPT, by respectively employing pyrene\u2010fused phenaziothiadiazoles and pyrene\u2010fused bisphenaziothiadiazoles as acceptor skeletons. There is strength in numbers by increasing the fusing rings in\n                    <jats:italic>N<\/jats:italic>\n                    \u2010heteroacenes moieties and numbers of appended donors. Compared to less ring\u2010fused 2TT\u2010PPT, the giant molecule 4TT\u2010PBPT shows improved photophysical characteristics, such as enhanced light absorbance, red\u2010shifted wavelengths, higher brightness, favorable reactive oxygen species (ROS) generation, and elevated photothermal conversion efficiency, which render 4TT\u2010PBPT nanoparticles excellent fluorescence\u2010photoacoustic\u2010photothermal trimodal imaging guided photodynamic\u2010photothermal synergistic therapy for orthotopic bladder cancer.\n                  <\/jats:p>","DOI":"10.1002\/anie.202417865","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T07:08:59Z","timestamp":1730185739000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Strength in Numbers: A Giant NIR\u2010II AIEgen with One\u2010for\u2010All Phototheranostic Features for Exceptional Orthotopic Bladder Cancer Treatment"],"prefix":"10.1002","volume":"64","author":[{"given":"Caifa","family":"You","sequence":"first","affiliation":[{"name":"Center for AIE Research, Guangdong Provincial Key Laboratory of New Energy Materials Service Safety, College of Materials Science and Engineering Shenzhen University  Shenzhen 518060 P. 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