{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:29:54Z","timestamp":1786976994324,"version":"build-2736575974"},"reference-count":63,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,2,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hydrogen persulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>2<\/jats:sub>\n                    ) plays a significant role in redox biology and signal transduction; therefore, quantitative visualization of H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>2<\/jats:sub>\n                    in the deep tissue of living organisms is essential for obtaining reliable information about relevant pathophysiological processes directly. However, currently reported H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>2<\/jats:sub>\n                    probes are unsuitable for this purpose because of their poor selectivity for many polysulfide species or their short wavelength, which hinders precise imaging in deep tissues. Herein, for the first time, we report a unique H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>2<\/jats:sub>\n                    \u2010mediated dithiole formation reaction. Based on this reaction, we construct the first NIR\u2010II fluorescence (FL) and photoacoustic (PA) dual\u2010ratiometric probe (\n                    <jats:bold>\n                      NIR\u2010II\u2010H\n                      <jats:sub>2<\/jats:sub>\n                      S\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:bold>\n                    ) for quantitatively visualizing H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>2<\/jats:sub>\n                    in vivo. This probe shows dual\u2010ratiometric NIR\u2010II fluorescence (I\n                    <jats:sub>840<\/jats:sub>\n                    \/I\n                    <jats:sub>1000<\/jats:sub>\n                    , 107\u2010fold) and photoacoustic (PA\n                    <jats:sub>800<\/jats:sub>\n                    \/PA\n                    <jats:sub>900<\/jats:sub>\n                    , 6.5\u2010fold) responses towards Na\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>2<\/jats:sub>\n                    species with high specificity, excellent sensitivity (1.8\u2005nM), improved water solubility, and deep\u2010tissue penetration. More importantly, using NIR\u2010II dual\u2010ratiometric FL\/PA imaging, we successfully demonstrated that the probe could be used to accurately quantify the fluctuating H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>2<\/jats:sub>\n                    levels in the liver\u2010injury mouse models induced by lipopolysaccharides or metformin drugs. Overall, this study not only presents a promising tool for H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>2<\/jats:sub>\n                    \u2010related pathological research, but also provides a unique recognition site that may be generalized for designing more useful H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>2<\/jats:sub>\n                    imaging agents in the future.\n                  <\/jats:p>","DOI":"10.1002\/anie.202418378","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T06:33:48Z","timestamp":1731479628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["NIR\u2010II Fluorescence\/Photoacoustic Dual Ratiometric Probes with Unique Recognition Site for Quantitatively Visualizing H\n                    <sub>2<\/sub>\n                    S\n                    <sub>2<\/sub>\n                    <i>in Vivo<\/i>"],"prefix":"10.1002","volume":"64","author":[{"given":"Bangping","family":"Hu","sequence":"first","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China) Collaborative Innovation Center for Guangxi Ethnic Medicine School of Chemistry and Pharmaceutical Sciences Guangxi Normal University  Guilin 541004 P. 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