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We propose a dual\u2010functional nanogel complex armed with the antimicrobial drug triclosan (TCS) and the pro\u2010angiogenesis medication deferoxamine (DFO) for combating microbial pathogens and promoting tissue regeneration. The nanogel system (NG\u2010TCS\u2010DFO) that we fabricated from linear polyglycerol exhibits well\u2010defined spherical morphology and a positively charged surface for bacteria adhesion. The rapid and sustained degradation of NG\u2010TCS\u2010DFO in the acidic environment of an infection site induces the on\u2010demand release of TCS and DFO. The NG\u2010TCS\u2010DFO shows potent bacteria elimination of the gingivitis\u2010causing bacteria\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    in both planktonic (99.9\u2009%) and biofilm (99\u2009%) states. Furthermore, the NG\u2010TCS\u2010DFO can promote vascularization and migration of human umbilical vein endothelial cells (HUVECs). Contributing to the synergistic effect of TCS and DFO, the NG\u2010TCS\u2010DFO demonstrates significant bone tissue regeneration and accelerated healing of periodontitis in vivo. This polyglycerol\u2010based nanogel may therefore offer smart combined delivery of multiple therapeutics against bacteria\u2010driven diseases.\n                  <\/jats:p>","DOI":"10.1002\/anie.202418882","type":"journal-article","created":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T23:00:40Z","timestamp":1737327640000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["pH\u2010Responsive Polyglycerol Nanogels for Periodontitis Treatment through Antibacterial and Pro\u2010Angiogenesis Action"],"prefix":"10.1002","volume":"64","author":[{"given":"Guoxin","family":"Ma","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Chemie und Biochemie Freie Universit\u00e4t Berlin  Takustr. 3 Berlin 14195 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Clinical Research 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