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Herein, we propose an innovative strategy for the intracellular co\u2010delivery of carbon monoxide (CO) and nitric oxide (NO) gasotransmitters under clinically relevant wavelengths. This approach rationally couples aerobic photooxidative and anaerobic photocatalytic reactions within a polymeric micelle platform, using palladium(II) tetraphenyltetrabenzoporphyrin (PdTPTBP) as both photosensitizer and photocatalyst. Notably, the photooxidation\u2010mediated release of CO generates a local hypoxic microenvironment, which facilitates the photoredox catalyzed release of NO. This self\u2010adaptive micelle platform enables efficient uptake by tumor cells and intracellular co\u2010delivery of CO and NO under 630\u2005nm light irradiation, demonstrating potent anti\u2010tumor activity in a 4T1 tumor\u2010bearing mouse model via the synergistic induction of mitochondrial apoptosis.<\/jats:p>","DOI":"10.1002\/anie.202419939","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T04:54:49Z","timestamp":1736398489000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Intracellular Co\u2010Delivery of Carbon Monoxide and Nitric Oxide Induces Mitochondrial Apoptosis for Cancer Therapy"],"prefix":"10.1002","volume":"64","author":[{"given":"Zhiqiang","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Pharmacy The First Affiliated Hospital of University of Science and Technology of China (USTC), and School of Biomedical Engineering, Division of 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