{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:55:09Z","timestamp":1790571309929,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014911","name":"Ministerstvo Obrany \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["Project No: DZRO-FVZ22-ZHN II"],"award-info":[{"award-number":["Project No: DZRO-FVZ22-ZHN II"]}],"id":[{"id":"10.13039\/501100014911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["project No. 22-24384S"],"award-info":[{"award-number":["project No. 22-24384S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018512","name":"Univerzita Hradec Kr\u00e1lov\u00e9","doi-asserted-by":"publisher","award":["Excellence project no. 2201-2024"],"award-info":[{"award-number":["Excellence project no. 2201-2024"]}],"id":[{"id":"10.13039\/100018512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["SVV 260 666"],"award-info":[{"award-number":["SVV 260 666"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016398","name":"Minist\u00e8re des Arm\u00e9es","doi-asserted-by":"publisher","award":["DGA\/SSA - NBC-5-C-2316"],"award-info":[{"award-number":["DGA\/SSA - NBC-5-C-2316"]}],"id":[{"id":"10.13039\/501100016398","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["UHHK 00179906"],"award-info":[{"award-number":["UHHK 00179906"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["UMO-2021\/41\/B\/NZ7\/02825"],"award-info":[{"award-number":["UMO-2021\/41\/B\/NZ7\/02825"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and behavioral and psychological symptoms of dementia (BPSD). Given that cholinergic neurons are predominantly affected in AD, current treatments primarily aim to enhance cholinergic neurotransmission. However, imbalances in other neurotransmitters, such as \u03b3\u2010aminobutyric acid (GABA), also contribute to AD symptomatology. In the presented research, using a combination of crystallography and computational methods we developed compound\n                    <jats:bold>6<\/jats:bold>\n                    as a dual modulator of GABAergic and cholinergic neurotransmission systems. Compound\n                    <jats:bold>6<\/jats:bold>\n                    demonstrated inhibition of BuChE (IC\n                    <jats:sub>50<\/jats:sub>\n                    =0.21\u2005\u03bcM) and GABA transporter 1 (IC\n                    <jats:sub>50<\/jats:sub>\n                    =10.96\u2005\u03bcM) and 3 (IC\n                    <jats:sub>50<\/jats:sub>\n                    =7.76\u2005\u03bcM), along with a favorable drug\u2010likeness profile. Subsequent in vivo studies revealed the effectiveness of\n                    <jats:bold>6<\/jats:bold>\n                    in enhancing memory retention and alleviating anxiety and depression symptoms in animal models, while also proving safe and bioavailable for oral administration. The innovative multi\u2010target\u2010directed ligand\n                    <jats:bold>6<\/jats:bold>\n                    offers a new approach to treating cognitive deficits and BPSD in AD.\n                  <\/jats:p>","DOI":"10.1002\/anie.202420510","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T03:58:11Z","timestamp":1731297491000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Multifunctional, Fluorene\u2010Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3211-7188","authenticated-orcid":false,"given":"Dawid","family":"Panek","sequence":"first","affiliation":[{"name":"Department of Physicochemical Drug Analysis Faculty of Pharmacy Jagiellonian University Medical College  Medyczna St.\u20059 30-688 Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5426-9123","authenticated-orcid":false,"given":"Anna","family":"Pasieka","sequence":"additional","affiliation":[{"name":"Department of Physicochemical Drug Analysis Faculty of Pharmacy Jagiellonian University Medical College  Medyczna St.\u20059 30-688 Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9731-908X","authenticated-orcid":false,"given":"Jakub","family":"Jo\u0144czyk","sequence":"additional","affiliation":[{"name":"Department of Physicochemical Drug Analysis Faculty of Pharmacy Jagiellonian University Medical College  Medyczna St.\u20059 30-688 Cracow Poland"},{"name":"Sano Centre for Computational Medicine  Czarnowiejska 36 30-054 Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Gawli\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Physicochemical Drug Analysis Faculty of Pharmacy Jagiellonian University Medical College  Medyczna St.\u20059 30-688 Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5037-6183","authenticated-orcid":false,"given":"Paula","family":"Zar\u0119ba","sequence":"additional","affiliation":[{"name":"Department of Physicochemical Drug Analysis Faculty of Pharmacy Jagiellonian University Medical College  Medyczna St.\u20059 30-688 Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5321-9266","authenticated-orcid":false,"given":"Agata","family":"Siwek","sequence":"additional","affiliation":[{"name":"Department of Pharmacobiology Faculty of Pharmacy Jagiellonian University Medical College  Medyczna St. 9 30-688 Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3161-0878","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Wolak","sequence":"additional","affiliation":[{"name":"Department of Pharmacobiology Faculty of Pharmacy Jagiellonian University Medical College  Medyczna St. 9 30-688 Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7906-0353","authenticated-orcid":false,"given":"Barbara","family":"Mordyl","sequence":"additional","affiliation":[{"name":"Department of Pharmacobiology Faculty of Pharmacy Jagiellonian University Medical College  Medyczna St. 9 30-688 Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1632-6569","authenticated-orcid":false,"given":"Monika","family":"G\u0142uch\u2010Lutwin","sequence":"additional","affiliation":[{"name":"Department of Pharmacobiology Faculty of Pharmacy Jagiellonian University Medical College  Medyczna St. 9 30-688 Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9247-2598","authenticated-orcid":false,"given":"Gniewomir","family":"Latacz","sequence":"additional","affiliation":[{"name":"Department of Technology and Biotechnology of Drugs Faculty of Pharmacy Jagiellonian University Medical College  Medyczna St. 9 30-688 Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9219-1032","authenticated-orcid":false,"given":"Xavier","family":"Brazzolotto","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Toxicologie et Risques Chimiques Institut de Recherche Biom\u00e9dicale des Arm\u00e9es  91223 Br\u00e9tigny sur Orge France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5982-8265","authenticated-orcid":false,"given":"Fabien","family":"Chantegreil","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Toxicologie et Risques Chimiques Institut de Recherche Biom\u00e9dicale des Arm\u00e9es  91223 Br\u00e9tigny sur Orge France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0293-2429","authenticated-orcid":false,"given":"Florian","family":"Nachon","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Toxicologie et Risques Chimiques Institut de Recherche Biom\u00e9dicale des Arm\u00e9es  91223 Br\u00e9tigny sur Orge France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-9591","authenticated-orcid":false,"given":"Jana","family":"Zdarova Karasova","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Military Pharmacy Military Faculty of Medicine University of Defence in Brno  Trebesska 1575 500 02 Hradec Kralove Czech Republic"},{"name":"Biomedical Research Center University Hospital Hradec Kralove  Sokolska 581 500 05 Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2228-7922","authenticated-orcid":false,"given":"Jaroslav","family":"Pejchal","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Military Pharmacy Military Faculty of Medicine University of Defence in Brno  Trebesska 1575 500 02 Hradec Kralove Czech Republic"},{"name":"Biomedical Research Center University Hospital Hradec Kralove  Sokolska 581 500 05 Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4649-7828","authenticated-orcid":false,"given":"Martin","family":"Mzik","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry University Hospital Hradec Kralove  Sokolska 581 500 05 Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4688-2577","authenticated-orcid":false,"given":"Vit","family":"Sestak","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry University Hospital Hradec Kralove  Sokolska 581 500 05 Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9698-4478","authenticated-orcid":false,"given":"Lukas","family":"Prchal","sequence":"additional","affiliation":[{"name":"Biomedical Research Center University Hospital Hradec Kralove  Sokolska 581 500 05 Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0628-9865","authenticated-orcid":false,"given":"Jitka","family":"Odvarkova","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Military Pharmacy Military Faculty of Medicine University of Defence in Brno  Trebesska 1575 500 02 Hradec Kralove Czech Republic"},{"name":"Biomedical Research Center University Hospital Hradec Kralove  Sokolska 581 500 05 Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6376-8701","authenticated-orcid":false,"given":"Ondrej","family":"Soukup","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Military Pharmacy Military Faculty of Medicine University of Defence in Brno  Trebesska 1575 500 02 Hradec Kralove Czech Republic"},{"name":"Biomedical Research Center University Hospital Hradec Kralove  Sokolska 581 500 05 Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6977-7596","authenticated-orcid":false,"given":"Jan","family":"Korabecny","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Military Pharmacy Military Faculty of Medicine University of Defence in Brno  Trebesska 1575 500 02 Hradec Kralove Czech Republic"},{"name":"Biomedical Research Center University Hospital Hradec Kralove  Sokolska 581 500 05 Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7829-3980","authenticated-orcid":false,"given":"Ales","family":"Sorf","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Military Pharmacy Military Faculty of Medicine University of Defence in Brno  Trebesska 1575 500 02 Hradec Kralove Czech Republic"},{"name":"Department of Social and Clinical Pharmacy Faculty of Pharmacy in Hradec Kralove Charles University  Akademika Heyrovskeho 1203 Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Hamsikova","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science University of Hradec Kralove  Rokitanskeho 62 500 03 Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2732-5935","authenticated-orcid":false,"given":"Lucie","family":"Zemanova","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science University of Hradec Kralove  Rokitanskeho 62 500 03 Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6693-6061","authenticated-orcid":false,"given":"Lubica","family":"Muckova","sequence":"additional","affiliation":[{"name":"Biomedical Research Center University Hospital Hradec Kralove  Sokolska 581 500 05 Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1827-9308","authenticated-orcid":false,"given":"Nela","family":"V\u00e1nova","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Faculty of Pharmacy in Hradec Kralove Charles University  Akademika Heyrovskeho 1203 Hradec Kralove 500 05 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pola","family":"Dryja","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics Chair of Pharmacodynamics Faculty of Pharmacy Jagiellonian University Medical College  Medyczna St.\u20059 30-688 Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0614-5393","authenticated-orcid":false,"given":"Kinga","family":"Sa\u0142at","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics Chair of Pharmacodynamics Faculty of Pharmacy Jagiellonian University Medical College  Medyczna St.\u20059 30-688 Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7957-4503","authenticated-orcid":false,"given":"Georg","family":"H\u00f6fner","sequence":"additional","affiliation":[{"name":"Department of Pharmacy \u2013 Center for Drug Research Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen  Butenandtstr.\u20055\u201313 81377 Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4399-1425","authenticated-orcid":false,"given":"Klaus","family":"Wanner","sequence":"additional","affiliation":[{"name":"Department of Pharmacy \u2013 Center for Drug Research Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen  Butenandtstr.\u20055\u201313 81377 Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Wi\u0119ckowska","sequence":"additional","affiliation":[{"name":"Department of Physicochemical Drug Analysis Faculty of Pharmacy Jagiellonian University Medical College  Medyczna St.\u20059 30-688 Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4637-5820","authenticated-orcid":false,"given":"Barbara","family":"Malawska","sequence":"additional","affiliation":[{"name":"Department of Physicochemical Drug Analysis Faculty of Pharmacy Jagiellonian University Medical College  Medyczna St.\u20059 30-688 Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"key":"e_1_2_3_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.05.2410"},{"key":"e_1_2_3_3_1","volume":"24","author":"Yang Z.","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161118"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-023-01938-w"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3639"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2022.102331"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2020.04.008"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2014.11.003"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.10.019"},{"key":"e_1_2_3_11_1","volume":"5","author":"Wu Z.","year":"2014","journal-title":"Nat. Commun."},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113397"},{"key":"e_1_2_3_13_1","author":"Borden L.","year":"1994","journal-title":"Recept. Channels"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.5b00150"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201200126"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e318282dda7"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.05982.x"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2018.00397"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00041a012"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.04.063"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22122098"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00356"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201200126"},{"key":"e_1_2_3_24_1","first-page":"391","volume":"76","author":"Lynch T.","year":"2007","journal-title":"Am Fam Physician"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202420510","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202420510","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202420510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:58:46Z","timestamp":1790567926000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202420510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,22]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,2,3]]}},"alternative-id":["10.1002\/anie.202420510"],"URL":"https:\/\/doi.org\/10.1002\/anie.202420510","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,22]]},"assertion":[{"value":"2024-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202420510"}}