{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T05:08:28Z","timestamp":1789276108827,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22371053, 21674022, 223B2103, 51703034"],"award-info":[{"award-number":["22371053, 21674022, 223B2103, 51703034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,2,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S), one of the three gas signaling molecules, not only plays a vital role in mediating a series of cellular activities but also manifests exciting applications in clinical therapy. However, one main obstacle in using H\n                    <jats:sub>2<\/jats:sub>\n                    S as a gaseous therapeutic agent is to realize on\u2010demand storage and delivery of gas, and thus, it is of great importance to develop H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010donating vehicle platforms. Although a variety of polymer\u2010based gas\u2010releasing carriers have been designed, almost all the systems are limited to spherical structures. Here we explore the role of polymer self\u2010assembled morphologies, especially toward those non\u2010spherical nanostructures, on the H\n                    <jats:sub>2<\/jats:sub>\n                    S release capacity. A kind of tubular polymersomes (i.e. tubesomes), formed by the membrane stretching of polythionoester\u2010containing block copolymer vesicles, exhibit enhanced cysteine\u2010responsive H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010releasing behavior in contrast to their spherical counterparts. Moreover, we found that the amount and rate of H\n                    <jats:sub>2<\/jats:sub>\n                    S release from diverse polymersomes is relied on the extent of membrane elongation, which allows us to regulate the gas releasing kinetics through tailoring the membrane geometries. More importantly, it is demonstrated that the tubesomes as polymer\u2010type H\n                    <jats:sub>2<\/jats:sub>\n                    S donors have better anticancer performance than those spherical polymersomes. This would inspire new possibilities to boost gas therapeutic efficacy through shaping the morphology of gas nanovehicles.\n                  <\/jats:p>","DOI":"10.1002\/anie.202421405","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T22:49:40Z","timestamp":1736549380000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Gas\u2010Releasing Polymer Tubesomes: Boosting Gas Delivery of Nanovehicles via Membrane Stretching"],"prefix":"10.1002","volume":"64","author":[{"given":"Cuiqin","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science Fudan University  No.220, Handan Rd. Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulian","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science Fudan University  No.220, Handan Rd. Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Chemical and Biologic Information Nanjing University of Posts and Telecommunications  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science Fudan University  No.220, Handan Rd. Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5523-2659","authenticated-orcid":false,"given":"Qiang","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science Fudan University  No.220, Handan Rd. 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