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However, the dynamic production of exercise\u2010induced RONS remains poorly explored, due to the lack of sensing tools that can conform to soft skeletal muscle while monitor RONS release during exercise. Here we introduce dual flexible sensors via twisting carbon nanotubes into helical bundles of fibers and subsequent assembling electrochemical sensing components. These flexible sensors exhibit low bending stiffness, excellent H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and NO sensing abilities, outstanding biocompatibility and compliance with engineered skeletal muscle tissue. This allows real\u2010time and simultaneous monitoring of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and NO release from engineered skeletal muscle in response to different exercise\u2010mimicking stretches, which reveals that warm\u2010up activities before high\u2010intensity exercise may enhance adaptive responses by down\u2010regulating H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and up\u2010regulating NO production. The proposed sensing strategy demonstrates great versatility in monitoring multiple biomarkers of soft tissue and organs.\n                  <\/jats:p>","DOI":"10.1002\/anie.202421684","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T10:34:06Z","timestamp":1734950046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Flexible Fiber Sensors for Real\u2010Time Monitoring of Redox Signaling Molecules in Exercise\u2010Mimicking Engineered Skeletal Muscle"],"prefix":"10.1002","volume":"64","author":[{"given":"Jia\u2010Xin","family":"Li","sequence":"first","affiliation":[{"name":"College of Chemistry and Molecular Sciences Wuhan University  Wuhan 430072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Ting","family":"Fan","sequence":"additional","affiliation":[{"name":"Core Facility of Wuhan University Wuhan University  Wuhan 430072 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