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Bipyrroles served as carbon\u2010based nucleophiles to undergo Cu\u2010catalyzed C\u2212C coupling during the MCP. Upon post\u2010MCP modification by transforming the bipyrrole unit to boron dipyrromethene (BODIPY) and the sulfonylimide moiety to sulfonamide, poly(BODIPY\u2010sulfonamide)s (PBSAs) were obtained as potent anticancer therapeutic agents. This study disclosed the decomposition and SO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010releasing ability of PBSAs under ultrasound (US) irradiation. Furthermore, one of these polymers having a reactive oxygen species\u2010cleavable thioketal linker was modified with triethylene glycol chains to give\n                    <jats:bold>PBSA\u2010EG<\/jats:bold>\n                    , which was further studied for in vitro and in vivo US\u2010induced anti\u2010cancer therapy. Upon tail veil administration of\n                    <jats:bold>PBSA\u2010EG<\/jats:bold>\n                    nanoparticles into tumor\u2010bearing mice followed by US irradiation, remarkable tumor suppression was observed. This study demonstrates that the innovative and efficient MCP method can construct polymers bearing the BODIPY\u2010sulfonamide moieties, which show a great potential as safe and potent materials for combined gas and sonodynamic therapy against cancer.\n                  <\/jats:p>","DOI":"10.1002\/anie.202422362","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T08:24:00Z","timestamp":1736238240000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Multicomponent Polymerization toward Poly(BODIPY\u2010sulfonamide)s as Unique SO\n                    <sub>2<\/sub>\n                    Generators for Sonodynamic and Gas Combination Therapy"],"prefix":"10.1002","volume":"64","author":[{"given":"Shuxin","family":"Liu","sequence":"first","affiliation":[{"name":"School of Chemical Engineering Dalian University of Technology  Dalian 116024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Comparative Medicine Laboratory Animal Center Dalian Medical University  Dalian 116000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiguo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Comparative Medicine Laboratory Animal Center Dalian Medical University  Dalian 116000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis K. 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