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Steady State Free Precession (SSFP) NMR collects the signal in a steady state regime, allowing 100\u2019s of acquisitions in the timespan of a single traditional NMR scan. Unfortunately, data truncation from SSFP leads to artifacts and spectral broadening with Fourier transform, hindering interpretation. When non\u2010Fourier based time\u2010domain analysis is used, namely, complete reduction to amplitude frequency tables (CRAFT), limitations of SSFP are eliminated while sensitivity gains are retained. This work introduces the combined approach, then applies it for the measurement of PFCs in environmental and biological samples. In all cases, the approach reduces analysis time from many hours to minutes and\/or greatly increases the range of compounds detected. For example, when PFOA was spiked into human blood, the detection limit improved ~50\u2010fold vs standard NMR, while in a standard mixture, the approach detected compounds missed by LC\u2010MS\/MS. The technique can be adapted to any nucleus providing a facile approach to reduce experiment time and improve sensitivity of NMR in general.<\/jats:p>","DOI":"10.1002\/anie.202422971","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T17:08:46Z","timestamp":1738084126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Steady State Free Precession NMR without Fourier Transform: Redefining the Capabilities of <sup>19<\/sup>F NMR as a Discovery Tool"],"prefix":"10.1002","volume":"64","author":[{"given":"Jeremy R.","family":"Gauthier","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Toronto  80 St George Street Toronto, ON M5S 3H6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Kock","sequence":"additional","affiliation":[{"name":"Physical and Environmental Sciences University of Toronto Scarborough  1265 Military Trail Toronto, ON M1C 1A4 Canada"},{"name":"Departamento de Ciencias, Qu\u00edmica Centro de Espectroscopia de Resonancia Magn\u00e9tica Nuclear (CERMN) Pontificia Universidad Cat\u00f3lica del Per\u00fa  Av. 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