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However, direct access to enantioenriched \u03b1\u2010aminoketones from simple and readily available starting materials remains a formidable challenge. Herein, we report an unprecedented nickel\u2010catalyzed asymmetric cross\u2010coupling protocol for the synthesis of enantioenriched \u03b1\u2010\n                    <jats:italic>N<\/jats:italic>\n                    \u2010heteroaryl ketones from alkenes and enamines in the presence of a carbon monoxide surrogate. The success of this reaction relies on the sorting of two different alkenes along with the control of regio\u2010 and enantioselectivity. This reductive\u2010oxidative carbonylation of enamines and unactivated alkenes featuring the use of a carbon monoxide surrogate allows for the gas\u2010free streamlined assembly of enantioenriched \u03b1\u2010\n                    <jats:italic>N<\/jats:italic>\n                    \u2010heteroaryl ketones from two distinct alkenes.\n                  <\/jats:p>","DOI":"10.1002\/anie.202423426","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T20:53:40Z","timestamp":1741726420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Synthesis of \u03b1\u2010N\u2010Heteroaryl Ketones by Nickel\u2010Catalyzed Chemo\u2010, Regio\u2010 and Enantioselective Carbonylation of Alkenes and\n                    <i>N<\/i>\n                    \u2010Alkenyl Heteroarenes"],"prefix":"10.1002","volume":"64","author":[{"given":"Xiao\u2010Yi","family":"Chen","sequence":"first","affiliation":[{"name":"Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Shenzhen Grubbs Institute, Guangming Advanced Research Institute, Department of Chemistry, and Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and Technology  Shenzhen 518055, Guangdong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Yu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Shenzhen Grubbs Institute, Guangming Advanced Research Institute, Department of Chemistry, and Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and Technology  Shenzhen 518055, Guangdong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0890-2634","authenticated-orcid":false,"given":"Wei","family":"Shu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Shenzhen Grubbs Institute, Guangming Advanced Research Institute, Department of Chemistry, and Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and Technology  Shenzhen 518055, Guangdong P. R. China"},{"name":"College of Chemistry and Environmental Engineering, Innovation Center for Chenguang High Performance Fluorine Material Sichuan University of Science and Engineering  Zigong 643000, Sichuan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"key":"e_1_2_3_1_1","unstructured":"\u00a0"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.10297"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm050797a"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm901189z"},{"key":"e_1_2_3_5_1","unstructured":"\u00a0"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0OB02098B"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201400236"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b04518"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b12315"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c07210"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja039103i"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja047704j"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol1005104"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja2056159"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja408296h"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b00229"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b03733"},{"key":"e_1_2_3_18_1","unstructured":"\u00a0"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201910168"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c10471"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c07851"},{"key":"e_1_2_3_22_1","unstructured":"\u00a0"},{"key":"e_1_2_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13274"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo500507s"},{"key":"e_1_2_3_25_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5QO00224A"},{"key":"e_1_2_3_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00162"},{"key":"e_1_2_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-017-0065"},{"key":"e_1_2_3_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00291"},{"key":"e_1_2_3_29_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS01107J"},{"key":"e_1_2_3_30_1","unstructured":"\u00a0"},{"key":"e_1_2_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201903330"},{"key":"e_1_2_3_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202204144"},{"key":"e_1_2_3_33_1","unstructured":"\u00a0"},{"key":"e_1_2_3_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja4117632"},{"key":"e_1_2_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14006"},{"key":"e_1_2_3_36_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b13155"},{"key":"e_1_2_3_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c11285"},{"key":"e_1_2_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44160-023-00239-0"},{"key":"e_1_2_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11129"},{"key":"e_1_2_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0669-y"},{"key":"e_1_2_3_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201813222"},{"key":"e_1_2_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21600-x"},{"key":"e_1_2_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22983-7"},{"key":"e_1_2_3_44_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c11630"},{"key":"e_1_2_3_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202208018"},{"key":"e_1_2_3_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202303795"},{"key":"e_1_2_3_47_1","unstructured":"\u00a0"},{"key":"e_1_2_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44160-024-00609-2"},{"key":"e_1_2_3_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44160-024-00635-0"},{"key":"e_1_2_3_50_2","unstructured":"P.-F. 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