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While trifluoromethylation of alkenes provides a powerful synthetic route to construct CF\n                    <jats:sub>3<\/jats:sub>\n                    \u2010containing compounds with broad structural and functional diversity, achieving enantioselective control in these reactions remains a formidable challenge. In this study, we engineered a nonheme iron enzyme, quercetin 2,3\u2010dioxygenase from\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    (\n                    <jats:italic>Bs<\/jats:italic>\n                    QueD), for the enantioselective trifluoromethylazidation of alkenes. Through directed evolution, the final variant\n                    <jats:italic>Bs<\/jats:italic>\n                    QueD\u2010CF\n                    <jats:sub>3<\/jats:sub>\n                    exhibited excellent enantioselectivity, with an enantiomeric ratio (e.r.) of up to 98\u2009:\u20092. Preliminary mechanistic studies suggest the involvement of radical intermediates. This work expands biocatalytic organofluorine chemistry by reprogramming metalloenzymes for innovative trifluoromethylation reactions.\n                  <\/jats:p>","DOI":"10.1002\/anie.202423507","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T23:54:42Z","timestamp":1737676482000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Enantioselective Trifluoromethylazidation of Styrenyl Olefins Catalyzed by an Engineered Nonheme Iron Enzyme"],"prefix":"10.1002","volume":"64","author":[{"given":"Hua","family":"He","sequence":"first","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology Department of Biopharmaceutics West China School of Pharmacy Sichuan University  Chengdu 610041 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