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Notably, these molecules also exhibit lower inherent ototoxicity and nephrotoxicity than common aminoglycosides. Consequently, fortimicins are a promising type of protoypical molecules for the development of the next generation of aminoglycoside antibiotics. Here, we report the asymmetric total synthesis of fortimicin B in 12 steps (longest linear sequence, LLS) from readily available starting materials. An enantioselective Cu(II)\u2010catalyzed inverse\u2010electron\u2010demand Diels\u2013Alder (IEDDA) reaction of 2\u2010pyrones and\n                    <jats:italic>N<\/jats:italic>\n                    \u2010substituted 2\u2010oxazolones was developed for the efficient synthesis of the fortamine fragment, which previously required a lengthy multistep synthesis owing to its complex stereochemistry. The 6\u2010\n                    <jats:italic>epi<\/jats:italic>\n                    \u2010purpurosamine B fragment was efficiently synthesized through a Cr(II)\/Co(I)\u2010mediated C\u2500C bond coupling between aldehydes and alkyl halides. Within these two fragments, the stereoselective construction of the \u03b1\u2010glycosidic bond of fortimicin B was realized via the gold(I)\u2010catalyzed glycosylation. Overall, this study provides an efficient synthetic platform for future investigations into the structure\u2013activity relationships of fortimicins.\n                  <\/jats:p>","DOI":"10.1002\/anie.202424235","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T10:15:06Z","timestamp":1741860906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Enantioselective Total Synthesis of Fortimicin B"],"prefix":"10.1002","volume":"64","author":[{"given":"Yang","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Chemistry Fudan University  220 Handan Rd. Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Yu","family":"You","sequence":"additional","affiliation":[{"name":"Department of Chemistry Fudan University  220 Handan Rd. 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