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We show that high\u2010performance, low\u2010threshold\u2010voltage n\u2010type OMIEC polymers can be achieved using a simple diketopyrrolopyrrole unit flanked by thiazole groups, which is functionalized with glycolated side chains. Interestingly, the regiospecific sp\n                    <jats:sup>2<\/jats:sup>\n                    \u2010N position in the repeating unit's thiazole governs the polymer chains' solvation and molecular packing. This specific backbone chemistry enhances conjugation efficiency, reduces trap density, and improves electrochemical doping efficiency. Moreover, systematic variation of glycolated side\u2010chain lengths induces a sequential shift in molecular orientation\u2014from edge\u2010on through bimodal to face\u2010on preferential alignment. This structural evolution achieves optimized ionic\u2010electronic transport balance, resulting in exceptional device metrics: a geometrically normalized transconductance of 31.9 S\u00a0cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    , a figure\u2010of\u2010merit\n                    <jats:italic>\u00b5C<\/jats:italic>\n                    * of 96.3\u00a0F\u00a0cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00a0V\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00a0s\n                    <jats:sup>\u22121<\/jats:sup>\n                    , and a threshold voltage of 0.31\u00a0V, positioning these materials among the highest\u2010performing n\u2010type OMIECs. An organic complementary inverter made from the optimized n\u2010type OMIEC polymer and a reported p\u2010type polymer exhibits a voltage gain of 198\u00a0V\u00a0V\n                    <jats:sup>\u22121<\/jats:sup>\n                    , effectively amplifying the ECG signal and enhancing signal quality. This work establishes structure\u2010property guidelines for designing bioelectronic n\u2010type OMIECs.\n                  <\/jats:p>","DOI":"10.1002\/anie.202424820","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T03:14:02Z","timestamp":1742008442000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Regiochemistry and Side\u2010Chain Engineering Enable Efficient N\u2010Type Mixed Conducting Polymers"],"prefix":"10.1002","volume":"64","author":[{"given":"Mingyu","family":"Ma","sequence":"first","affiliation":[{"name":"State Key Laboratory of Polymer Science and Technology Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P.R. China"},{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China  Hefei 230026 P.R. 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