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YIM10. Extensive NMR and MS analyses revealed a halogenated peptide core comprising four amino acids cyclized via a ureido linkage with an exocyclic 2\u2010hydroxy\u20103\u2010(4\u2010hydroxyphenyl)propyl residue connected to a five\u2010sugar\/aminosugar chain. Two of the three aminosugars constitute the\n                    <jats:italic>N<\/jats:italic>\n                    \u2010methylated and\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>O<\/jats:italic>\n                    \u2010dimethylated derivatives of eremosamine (4\u2010\n                    <jats:italic>epi<\/jats:italic>\n                    \u2010vancosamine) that have not been reported in any natural product. Saarvienin A exhibits potent activity against a range of Gram\u2010positive bacteria, effectively overcoming resistance to several frontline antibiotics in clinical isolates. It demonstrates an eight\u2010fold reduction in minimum inhibitory concentrations (MICs) against methicillin\u2010resistant, vancomycin\u2010intermediate, and daptomycin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    compared to vancomycin.\n                  <\/jats:p>","DOI":"10.1002\/anie.202425588","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T07:15:01Z","timestamp":1744960501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Saarvienin A\u2014A Novel Glycopeptide with Potent Activity against Drug\u2010Resistant Bacteria"],"prefix":"10.1002","volume":"64","author":[{"given":"Amninder","family":"Kaur","sequence":"first","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Helmholtz Centre for Infection Research (HZI) PharmaScienceHub (PSH) Saarland University Campus  66123 Saarbr\u00fccken Germany"},{"name":"German Centre for Infection Research (DZIF) Partner Site Hannover\u2010Braunschweig  38124 Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime Felipe","family":"Guerrero\u2010Garz\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Division of Pharmacognosy University of Vienna  Vienna 1090 Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari","family":"Rasheed","sequence":"additional","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Helmholtz Centre for Infection Research (HZI) PharmaScienceHub (PSH) Saarland University Campus  66123 Saarbr\u00fccken Germany"},{"name":"German Centre for Infection Research (DZIF) Partner Site Hannover\u2010Braunschweig  38124 Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Zehl","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Chemistry University of Vienna  Vienna 1090 Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Fries","sequence":"additional","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Helmholtz Centre for Infection Research (HZI) PharmaScienceHub (PSH) Saarland University Campus  66123 Saarbr\u00fccken Germany"},{"name":"German Centre for Infection Research (DZIF) Partner Site Hannover\u2010Braunschweig  38124 Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Morgenstern","sequence":"additional","affiliation":[{"name":"Department of Chemistry Saarland University  66123 Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey B.","family":"Zotchev","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Division of Pharmacognosy University of Vienna  Vienna 1090 Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Helmholtz Centre for Infection Research (HZI) PharmaScienceHub (PSH) Saarland University Campus  66123 Saarbr\u00fccken Germany"},{"name":"German Centre for Infection Research (DZIF) Partner Site Hannover\u2010Braunschweig  38124 Braunschweig Germany"},{"name":"Department of Pharmacy Saarland University  66123 Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2014.111"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2018.02.009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a026989"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19990802)38:15<2096::AID-ANIE2096>3.0.CO;2-F"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr030103a"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3819"},{"key":"e_1_2_8_7_1","first-page":"710","volume":"342","author":"Murray B. 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