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Herein, we developed a visible light\u2010induced catalytic asymmetric\n                    <jats:italic>aza<\/jats:italic>\n                    \u2010Reformatsky reaction via a chiral Lewis acid\u2010assisted direct excitation of imines without additional reductants, enabling the carbon\u2013iodine bond cleavage of iododifluoromethyl ketones and the subsequent enantioselective radical coupling. This protocol provided an ingenious access to chiral\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010amino ketones containing a\n                    <jats:italic>gem<\/jats:italic>\n                    \u2010difluorine moiety. The mechanistic studies including radical trapping experiment, NMR experiment, electron paramagnetic resonance experiment, cyclic voltammetry experiment and spectroscopic analysis rationalized the reaction process.\n                  <\/jats:p>","DOI":"10.1002\/anie.202500756","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T09:10:40Z","timestamp":1739869840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Reductant\u2010Free Enantioselective\n                    <i>Aza<\/i>\n                    \u2010Reformatsky Reaction Enabled by Synergistic Visible Light Photocatalysis and Lewis Acid Catalysis"],"prefix":"10.1002","volume":"64","author":[{"given":"Mingyi","family":"Jiang","sequence":"first","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology Ministry of Education College of Chemistry Sichuan University  Chengdu 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengcheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology Ministry of Education College of Chemistry Sichuan University  Chengdu 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhan","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Natural Products Research Chengdu Institute of Biology Chinese Academy of Sciences  Chengdu 610047 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Natural Products Research Chengdu Institute of Biology Chinese Academy of Sciences  Chengdu 610047 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidi","family":"Cao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology Ministry of Education College of Chemistry Sichuan University  Chengdu 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology Ministry of Education College of Chemistry Sichuan University  Chengdu 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4507-0478","authenticated-orcid":false,"given":"Xiaoming","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology Ministry of Education College of Chemistry Sichuan University  Chengdu 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"e_1_2_3_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/cber.188702001268"},{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2004.07.018"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570179043485385"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2CS35351B"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200604344"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200604344"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201300571"},{"key":"e_1_2_3_7_1","first-page":"325","volume":"14","author":"Pellissier H.","year":"2018","journal-title":"J. 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