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Among hyperpolarization methods, Signal Amplification By Reversible Exchange (SABRE) is attractive because SABRE polarizes the substrates directly in room\u2010temperature solutions avoiding complex hardware. Most SABRE experiments have historically been performed in methanol, a relatively toxic and difficult\u2010to\u2010remove solvent. Here we demonstrate the use of a 80\/20 acetone\/water (A\/W) solvent system (Ace\u2010SABRE) to provide hyperpolarized [1\u2013\n                    <jats:sup>13<\/jats:sup>\n                    C]pyruvate with up to 17% polarization, then implement a solvent processing protocol to achieve injectable solutions retaining 74% of the initial polarization, and lastly we demonstrate HP in vivo spectroscopy and imaging using the Ace\u2010SABRE platform to showcase metabolic tracking in a hepatocellular carcinoma (HCC) tumor as well as HP\u2010MRI, both in direct comparison to dissolution dynamic nuclear polarization (d\u2010DNP) experiments. The Ace\u2010SABRE technique promises faster adoption of SABRE hyperpolarization in biological experiments, overall lowering the barriers to entry for HP\u2010NMR and HP\u2010MRI.\n                  <\/jats:p>","DOI":"10.1002\/anie.202501231","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:19:57Z","timestamp":1745446797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Scalable Hyperpolarized MRI Enabled by Ace\u2010SABRE of [1\u2010\n                    <sup>13<\/sup>\n                    C]Pyruvate"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9144-1423","authenticated-orcid":false,"given":"Stephen J.","family":"McBride","sequence":"first","affiliation":[{"name":"Department of Chemistry North Carolina State University  Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2896-5408","authenticated-orcid":false,"given":"Megan","family":"Pike","sequence":"additional","affiliation":[{"name":"Department of Chemistry North Carolina State University  Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Curran","sequence":"additional","affiliation":[{"name":"Department of Chemistry North Carolina State University  Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Zavriyev","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bukola","family":"Adebesin","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Tucker","sequence":"additional","affiliation":[{"name":"Vizma Life Sciences  Chapel Hill NC 27514 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared M.","family":"Harzan","sequence":"additional","affiliation":[{"name":"School of Chemical &amp; Biomolecular Sciences Southern Illinois University  Carbondale IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishani M.","family":"Senanayake","sequence":"additional","affiliation":[{"name":"School of Chemical &amp; Biomolecular Sciences Southern Illinois University  Carbondale IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5513-3658","authenticated-orcid":false,"given":"Mustapha","family":"Abdulmojeed","sequence":"additional","affiliation":[{"name":"Department of Chemistry North Carolina State University  Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6779-9978","authenticated-orcid":false,"given":"Franziska","family":"Theiss","sequence":"additional","affiliation":[{"name":"Department of Chemistry North Carolina State University  Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4320-2732","authenticated-orcid":false,"given":"Sheng","family":"Shen","sequence":"additional","affiliation":[{"name":"A. 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