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The development of synthetic donors with controllable release profiles is essential for elucidating H\n                    <jats:sub>2<\/jats:sub>\n                    S's complex involvement in cellular signaling, which remains a challenge. Herein, we report a diverse collection of photocaged N\u2010methylation thiocarbamates and thiocarbonates, designed to explore how electronic properties and the leaving efficiency of payloads affect H\n                    <jats:sub>2<\/jats:sub>\n                    S release behaviors. These compounds are engineered to release carbonyl sulfide (COS) following the removal of photoprotective group (PPG). The COS could be rapidly converted into H\n                    <jats:sub>2<\/jats:sub>\n                    S by carbonic anhydrase, and the entire reaction progression was monitored by changes in fluorescence signals. Furthermore, this H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010releasing platform is suitable for conjugation with active pharmaceutical ingredients, facilitating the creation of H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010releasing hybrid prodrugs. Collectively, this novel class of H\n                    <jats:sub>2<\/jats:sub>\n                    S donor not only provides valuable tool for H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010related research but also holds significant potential as therapeutic agent.\n                  <\/jats:p>","DOI":"10.1002\/anie.202501685","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:39:34Z","timestamp":1741739974000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Tunable Light\u2010Activated Platform for Controlled Hydrogen Sulfide Release with Tracking"],"prefix":"10.1002","volume":"64","author":[{"given":"Fang","family":"Yuan","sequence":"first","affiliation":[{"name":"Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education College of Chemistry and Materials Science Northwest University  Xi'an Shaanxi 710127 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoxin","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University  70 Nanyang Drive Singapore 637457 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education College of Chemistry and Materials Science Northwest University  Xi'an Shaanxi 710127 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Ning","sequence":"additional","affiliation":[{"name":"Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development College of Bioresources Chemical and Materials Engineering Shaanxi University of Science &amp; Technology  Xi'an 710021 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education College of Chemistry and Materials Science Northwest University  Xi'an Shaanxi 710127 P.R. China"},{"name":"Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing of the Ministry of Education School of Chemical Engineering Northwest University  Xi'an 710127 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education College of Chemistry and Materials Science Northwest University  Xi'an Shaanxi 710127 P.R. 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