{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:58:37Z","timestamp":1793066317466,"version":"4.5.0"},"reference-count":75,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,5,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Redox\u2010based diagnostic and therapeutic applications have long suffered from a shortage of suitable drugs and probes of high specificity. In the context of anti\u2010ferroptosis research for neurological diseases, the inaccessibility of a blood\u2013brain barrier (BBB) permeable small molecular ferroptosis inhibitor, and the lack of specific ferroptosis probes, seriously impeded a deeper understanding of the mechanism of ferroptosis and the development of clinically applicable drugs. We report herein a novel 1,3,4\u2010thiadiazole\u2010functionalized druglike ferrostatin analogue entitled\n                    <jats:bold>Ferfluor\u20101<\/jats:bold>\n                    with superior anti\u2010ferroptosis potency, favorable BBB permeability and in vivo activity against stroke and Parkinson's disease. Moreover, the exclusive pseudo\u2010excited\u2010state intramolecular proton\u2010transfer (ESIPT) property of\n                    <jats:bold>Ferfluor\u20101<\/jats:bold>\n                    via a long\u2010distance hydrogen\u2010bonding network makes it the first sensitive ratiometric photoluminescent probe to detect phospholipid hydroperoxides and a specific indicator for the fluctuation of ferroptosis. These unprecedented advantages not only make\n                    <jats:bold>Ferfluor\u20101<\/jats:bold>\n                    a potential tool for ferroptosis\u2010related diagnostic and therapeutic applications in the central nervous system, but also pave the way to developing new theragnostic agents for precision redox detection and regulation.\n                  <\/jats:p>","DOI":"10.1002\/anie.202502195","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:20:02Z","timestamp":1740176402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["A Druglike Ferrostatin\u20101 Analogue as a Ferroptosis Inhibitor and Photoluminescent Indicator"],"prefix":"10.1002","volume":"64","author":[{"given":"Jiangkun","family":"Yan","sequence":"first","affiliation":[{"name":"Key Laboratory of Marine Drug Ministry of Education School of Medicine and Pharmacy Ocean University of China  Qingdao 266003 China"},{"name":"Laboratory for Marine Drugs and Bioproducts Qingdao National Laboratory for Marine Science and Technology  Qingdao 266237 P.\u2005R. 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