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Nanomaterials represent promising tools to enable\u00a0wireless remote control of cells. To achieve this, the precise anchoring of nanomaterials to target cells is crucial for nanomaterial\u2010engineered cells to prevent undesired effects such as endocytosis and diffusion. Herein, we describe a general cell engineering strategy using nanomaterials to achieve remote\u2010controlled and sustained insulin release from the engineered pancreatic \u03b2 cells. The prepared nanocomposite, termed TCN, is composed of defect\u2010rich titanium oxide quantum dots with ultrasound\u2010electric conversion effect and fibrous carbon substrate. In vitro experiments demonstrate that the TCN enables cell surface engineering through carbon substrate adsorption onto pancreatic \u03b2 cells without chemical modification, while the TiO\n                    <jats:sub>x<\/jats:sub>\n                    quantum dots of TCN enable effective ultrasound\u2010responsive electrical stimulation to activate insulin release from \u03b2 cells. Furthermore, we demonstrate that the subcutaneous implantation of TCN\u2010engineered \u03b2 cell complexes in type 1 and type 2 diabetic mice enables the restoration of normoglycemia by ultrasound stimulation, establishing a nanomaterials\u2010enabled controlled cell therapy paradigm for diabetes.\n                  <\/jats:p>","DOI":"10.1002\/anie.202502780","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T11:46:13Z","timestamp":1753962373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sonoelectric Nanonet\u2010Activated Extracellular Electron Transfer for Wireless Non\u2010Genetic Stimulation of Pancreatic \u03b2 Cells"],"prefix":"10.1002","volume":"64","author":[{"given":"Yanling","family":"You","sequence":"first","affiliation":[{"name":"Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P.R. 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