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Traditional thrombolytic drugs are constrained by short half\u2010life, low utilization, and severe complications. Inspired by the tunnel boring machine to excavate strata into small rocks, we report urokinase plasminogen activator (uPA)\u2010modified thrombus boring microrobots (uTBMs), prepared by a one\u2010step integrated phase separation and interfacial self\u2010assembly process, for effective thrombolysis. The uTBMs are composed of microspheres capped with dual\u2010layered structures of magnetic nanoparticles (MNPs) and cilia nanostructures. In situ observation reveals the integrated phase separation and interfacial self\u2010assembly process of the uTBM within an emulsion droplet. The capped layer of MNPs allows for controllable motion and rotation behavior under the manipulation of a remote magnetic field. The uPA\u2010modified cilia nanostructures grasp and degrade the fibrin network, synergizing with the uTBMs rotation to mechanically excavate blood cells from thrombus individually, achieving \u223c8.5\u2010fold higher thrombolytic efficacy than uPA alone. This research demonstrates the feasibility of controllably fabricating and modifying complex\u2010structured microrobots via the simple process toward potential thrombus therapy.<\/jats:p>","DOI":"10.1002\/anie.202503221","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T22:09:09Z","timestamp":1746050949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Thrombus Boring Microrobot Prepared by an Integrated Phase Separation and Interfacial Self\u2010Assembly Process Toward Thrombolysis"],"prefix":"10.1002","volume":"64","author":[{"given":"Han","family":"Bao","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Bio\u2010inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Beijing 100190 P.R. China"},{"name":"University of Chinese Academy of Sciences (UCAS)  Beijing 101408 P.R. 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