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However, current nanomotors face limitations that compromise efficiency of drug utilization, including the use of inorganic materials with suboptimal soft interface and biocompatibility, uncontrollable drug release, insufficient directional control, and slow movement speeds. Herein, we present a novel near\u2010infrared (NIR) light\u2010driven porous unsymmetric nanomotor with ultrafast motion, which utilizes hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S)\u2010responsive cationic organic \u03c0\u2010electron structure\u2010based electrochromic material (\n                    <jats:bold>F1<\/jats:bold>\n                    <jats:sup>2+<\/jats:sup>\n                    ) for the payload and controlled release of anionic anticancer drugs, enabling synergistic cancer chemotherapy and immunotherapy. We demonstrate that the nanomotor can precisely target tumors driven by thermophoresis, tumor\u2010targeting peptide (RGD), and H\n                    <jats:sub>2<\/jats:sub>\n                    S (highly expressed in tumors and acted as chemoattractants), which induces chemotactic behavior to guide nanomotors into tumors. Once in the tumors, the cationic\n                    <jats:bold>F1<\/jats:bold>\n                    <jats:sup>2+<\/jats:sup>\n                    is reduced to the diene\n                    <jats:bold>F2<\/jats:bold>\n                    upon reaction with H\n                    <jats:sub>2<\/jats:sub>\n                    S, activating the nanomotor's NIR fluorescence for real\u2010time monitoring of drug delivery and release in vivo. Upon exposure to H\n                    <jats:sub>2<\/jats:sub>\n                    S, the nanomotor undergoes disassembly due to the disruption of electrostatic interactions between the anionic anticancer drugs and the cationic\n                    <jats:bold>F1<\/jats:bold>\n                    <jats:sup>2+<\/jats:sup>\n                    , leading to the precise and controlled drug release, ensuring uniform distribution across the tumor. This innovative strategy would open avenues for delivering mRNA vaccines or other anionic drugs.\n                  <\/jats:p>","DOI":"10.1002\/anie.202503297","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T21:05:20Z","timestamp":1742936720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A Light\u2010Driven Electrochromic Materials\u2010Based Nanomotor for H\n                    <sub>2<\/sub>\n                    S\u2010Controlled Drug Release in Synergistic Cancer Chemotherapy Immunotherapy"],"prefix":"10.1002","volume":"64","author":[{"given":"Luyan","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) School of Materials Science and Engineering Nanjing University of Posts and Telecommunications  9 Wenyuan Road Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) School of Chemistry and Life Sciences Nanjing University of Posts and Telecommunications  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Ishigaki","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Hokkaido University  N10 W8, North\u2010ward Sapporo 060\u20130810 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Tong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) School of Materials Science and Engineering Nanjing University of Posts and Telecommunications  9 Wenyuan Road Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangqi","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) School of Materials Science and Engineering Nanjing University of Posts and Telecommunications  9 Wenyuan Road Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Sustainability for Chemicals Energy and Environment (ISCE2), Agency for Science Technology and Research (A*STAR)  1 Pesek Road Singapore 627833 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Hokkaido University  N10 W8, North\u2010ward Sapporo 060\u20130810 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quli","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) School of Materials Science and Engineering Nanjing University of Posts and Telecommunications  9 Wenyuan Road Nanjing 210023 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