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To surmount these obstacles, the development of stimuli\u2010responsive polymer delivery platforms, predominantly leveraging the tumor microenvironment (TME), has emerged as a promising strategy. Therapeutic and diagnostic agents can be released controllably at the tumor site by virtue of the bond cleavage or hydrophobic to hydrophilic transformation of TME\u2010sensitive linkages in TME\u2010responsive systems, thus augmenting cancer treatment and imaging precision, while simultaneously attenuating the damage to healthy tissues and false imaging signals caused by non\u2010specific drug leakage. In this comprehensive review, we scrutinize recent studies of TME\u2010responsive polymer delivery platforms, encompassing pH\u2010, ROS\u2010, GSH\u2010, enzyme\u2010, and hypoxia\u2010responsive vectors, significantly from the perspective of their molecular design and responsive mechanism, and further summarizing their bio\u2010application in drug delivery and diagnostic imaging. 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