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In this work, we will demonstrate that the helical structure of a chiral PPA can be tamed by playing with two different external stimuli such as temperature and metal ions. Thus, when a metal ion salt is delivered to a chloroform solution of a chiral PPA to generate a chiral PPA (m.r.u.)\/M<jats:sup>n+<\/jats:sup> complex in a ratio of 1.0\/&lt;0.5\u00a0mol\/mol, a temperature\u2010responsive material is obtained. Interestingly, when the temperature is lowered to about 278\u2013283\u00a0K, the metal ion uncomplexes, which recovers the initial helical structure adopted by the PPA. This complexation\u2013decomplexation between the chiral PPA and the metal ions is fully reversible and triggers different asymmetry amplification effects\u2010helix inversion, screw\u2010sense induction or Sergeants\u2010and\u2010Soldiers (SaS), among others\u2014, allowing the creation of a temperature\u2010responsive helical polymer\u2013metal complex (HPMC) from a metal\u2010responsive helical polymer.<\/jats:p>","DOI":"10.1002\/anie.202503949","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T08:14:03Z","timestamp":1741940043000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Thermal Activation of Asymmetry Amplification Effects in Helical Polymer\u2013Metal Complexes"],"prefix":"10.1002","volume":"64","author":[{"given":"Manuel","family":"Fern\u00e1ndez\u2010M\u00edguez","sequence":"first","affiliation":[{"name":"Centro Singular de Investigaci\u00f3n en Qu\u00edmica 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