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We propose a novel gas\u2010assisted sonosensitizer\u2010loaded biomimetic nanoplatform, triggering ultrasonic\u2010sensitive tumor immunogenic cell death (ICD) and cascading immune activation. Upon ultrasound stimulation, the nanocore liberates reactive oxygen species and nitric oxide, generating highly toxic peroxynitrite (ONOO\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) in situ. The ONOO\n                    <jats:sup>\u2212<\/jats:sup>\n                    then orchestrated several intracellular events, including protein\n                    <jats:italic>S<\/jats:italic>\n                    \u2010nitrosylation, endoplasmic reticulum stress, Ca\n                    <jats:sup>2+<\/jats:sup>\n                    dyshomeostasis\u2010mediated mitochondrial dysfunction, and ICD\u2010enhanced immune cell recruitment. Furthermore, the biomimetic artificial dendritic cell (DC) membranes, from genetically engineered tumor cells, simultaneously present peptide\u2010major histocompatibility complex class I (pMHC\u2010I) and CD86, enabling homologous tumor targeting but also mimicking the antigen presentation and costimulatory signaling of DCs to directly activate infiltrating T lymphocytes. In multiple murine models, this nanovaccine demonstrated remarkable therapeutic efficacy, including tumor suppression, long\u2010lasting antitumor immunity, and tumor metastasis inhibition. The ultrasound\u2010responsive nanoDCs offer a promising paradigm for multifaceted immune boosters to address the challenges of immune tolerance and suboptimal patient response.\n                  <\/jats:p>","DOI":"10.1002\/anie.202504684","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T08:19:30Z","timestamp":1745396370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["NO\u2010Enhanced Sonodynamic Nanovesicles with Co\u2010Stimulatory Molecule Self\u2010Presentation for Multidimensional Tumor Immunotherapy"],"prefix":"10.1002","volume":"64","author":[{"given":"Lu","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Medical Materials and Devices Tianjin Key Laboratory of Biomedical Materials and Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin 300192 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Kang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Medical Materials and Devices Tianjin Key Laboratory of Biomedical Materials and Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin 300192 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjiao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Medical Materials and Devices Tianjin Key Laboratory of Biomedical Materials and Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin 300192 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuya","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Medical Materials and Devices Tianjin Key Laboratory of Biomedical Materials and Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin 300192 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyun","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials Ministry of Education Frontiers Science Center for Cell Responses and College of Life Sciences Nankai University  Tianjin 300071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Medical Materials and Devices Tianjin Key Laboratory of Biomedical Materials and Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin 300192 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Qi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials Ministry of Education Frontiers Science Center for Cell Responses and College of Life Sciences Nankai University  Tianjin 300071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Medical Materials and Devices Tianjin Key Laboratory of Biomedical Materials and Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin 300192 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00168"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1203486"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0014-x"},{"key":"e_1_2_7_4_1","first-page":"672","volume":"8","author":"Lei Q.","year":"2020","journal-title":"Cell Dev. 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