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However, CO\n                    <jats:sub>2<\/jats:sub>\n                    constitutes a notorious thermodynamic sink, which restricts this approach to activated or intrinsically reactive nucleophiles. To qualitatively assess the stability of CO\n                    <jats:sub>2<\/jats:sub>\n                    adducts, we present a computational approach that integrates quantum chemistry with statistical modeling to build a predictive workflow. The target property is the CO\n                    <jats:sub>2<\/jats:sub>\n                    affinity, specifically the negative Gibbs free reaction energy. This predictive workflow has been applied to 60 novel carbon\u2010centered nucleophiles, suggesting reactions that yield stable carboxylation adducts. The results have been validated through experimental methods for five carbanions, which include three stable and two unstable adducts in DMSO according to our predictions. In addition, we examined two further carbanions that were suggested to form stable CO\n                    <jats:sub>2<\/jats:sub>\n                    adducts in DMSO, to further assess the experimental protocol and broaden its scope to structurally distinct motifs.\n                  <\/jats:p>","DOI":"10.1002\/anie.202504934","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T08:42:14Z","timestamp":1763541734000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predicting the Stability of Base\u2010mediated C\u2500H Carboxylation Adducts Using Data Science Tools"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9829-3715","authenticated-orcid":false,"given":"Maike","family":"Eckhoff","sequence":"first","affiliation":[{"name":"TU Braunschweig Institute of Physical and Theoretical Chemistry  Gauss Str 17 38106 Braunschweig 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