{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:10:01Z","timestamp":1783732201697,"version":"3.55.0"},"reference-count":59,"publisher":"Wiley","issue":"30","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2022\/007372"],"award-info":[{"award-number":["CRG\/2022\/007372"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,7,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Deconstructive functionalization of cyclic molecules has recently emerged as a prominent strategy to access unique architectures that are challenging to prepare through traditional methods. While significant progress has been made in the deconstructive functionalization of cyclic alcohols and amines, the strategies for deconstructing cyclic ketones remain largely unexplored. The Dowd\u2013Beckwith reaction, a ring\u2010expansion of cyclic ketones, is a powerful method for synthesizing medium\u2010 and large\u2010ring compounds. Herein, we developed the first interrupted Dowd\u2013Beckwith (IDB) reaction for highly regioselective deconstructive functionalization of cyclic ketones using electricity as the sole oxidant. This protocol is widely applicable for the deconstruction of small, medium\u2010sized, and macrocyclic ketones bearing a diverse range of functional groups. Remarkably, various naturally occurring complex cyclic ketones were successfully deconstructed into acyclic molecules, which are difficult to access by known strategies. The method was applied to the asymmetric synthesis of planococcol, citrilol acetate, maconelliol, and its derivatives. Furthermore, the functional groups incorporated during the transformation provided versatile handles for subsequent synthetic modifications. Mechanistic experiments and computational studies support an oxidative radical\u2010polar crossover followed by deconstructive functionalization.<\/jats:p>","DOI":"10.1002\/anie.202505155","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T09:59:22Z","timestamp":1747648762000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Deconstructive Functionalization of Cyclic Ketones via Electrochemical Interrupted Dowd\u2013Beckwith Reaction"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9424-6460","authenticated-orcid":false,"given":"Tushar","family":"Singha","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry Indian Institute of Science  Bangalore 560012 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8852-5830","authenticated-orcid":false,"given":"Jyothirlatha V. 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