{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T14:54:58Z","timestamp":1764600898881,"version":"3.46.0"},"reference-count":49,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["RG\u2216R2\u2216232338"],"award-info":[{"award-number":["RG\u2216R2\u2216232338"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/W02702X\/1","EP\/W524359\/1","EP\/T517896\/1"],"award-info":[{"award-number":["EP\/W02702X\/1","EP\/W524359\/1","EP\/T517896\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Silylamides are important ligands in coordination chemistry for their ability to stabilise low coordination numbers and provide soluble, and even volatile, metal complexes. Such compounds provide valuable insights into the fundamental bonding and reactivity of their respective metals. Despite the wealth of homo\u2010 and heteroleptic hexamethyldisilazide complexes of divalent 3\n                    <jats:italic>d<\/jats:italic>\n                    ions (Sc\u2010Ni, Zn), attempts to access the corresponding divalent copper complexes have yielded only Cu(I) species. Herein, we demonstrate the stabilisation and isolation of a formally Cu(II) bis\u2010hexamethyldisilazide which was achieved by implementing novel digital chemistry tools. In order to successfully isolate (DMAP)Cu\n                    <jats:sup>II<\/jats:sup>\n                    (N{SiMe\n                    <jats:sub>3<\/jats:sub>\n                    }\n                    <jats:sub>2<\/jats:sub>\n                    )\n                    <jats:sub>2<\/jats:sub>\n                    (DMAP\u00a0=\u00a0N,N\u2010dimethylaminopyridine), we investigated the roles of the co\u2010ligand and silylamide transfer reagent in the kinetics of its formation. Crucial to these studies was our newly developed \u201ccobotic\u201d Schlenk line which provides\u00a0digital control of the atmosphere under which we conduct our highly reactive syntheses. In digitising Schlenk\u2010line handling, we have improved synthetic productivity by creating protocols for automated inertisation, solvent evaporation, liquid handling and crystallisation all while capturing reaction log data. Importantly, our Cu silylamide synthesis provides a case study showing that our cobotics approach allows for the discovery and isolation of unstable species which may remain elusive by traditional manual or fully autonomous methodologies.\n                  <\/jats:p>","DOI":"10.1002\/anie.202505408","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T13:53:38Z","timestamp":1748958818000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Cobotic, Digitally Controlled Schlenk\u2010line Unlocks Access to Elusive Lewis\u2010Base Stabilised Copper Bis(Disilylamides)"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7497-9667","authenticated-orcid":false,"given":"Nicola L.","family":"Bell","sequence":"first","affiliation":[{"name":"School of Chemistry University of Glasgow  Glasgow G12 8QQ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8003-6907","authenticated-orcid":false,"given":"Marina","family":"Gladkikh","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Glasgow  Glasgow G12 8QQ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8276-4862","authenticated-orcid":false,"given":"Cameron","family":"Fraser","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Glasgow  Glasgow G12 8QQ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4011-8228","authenticated-orcid":false,"given":"Mostafa","family":"Elsayed","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Glasgow  Glasgow G12 8QQ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6691-2377","authenticated-orcid":false,"given":"Emma","family":"Richards","sequence":"additional","affiliation":[{"name":"School of Chemistry Cardiff University, Translational Research Hub  Maindy Road Cardiff CD24 4HQ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4984-2952","authenticated-orcid":false,"given":"Richard Drummond","family":"Turnbull","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Glasgow  Glasgow G12 8QQ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201410744"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201710482"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2083-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201911062"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat0650"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2442-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adc8743"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44286-023-00024-y"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1109\/THMS.2021.3092684"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-021-01156-3"},{"key":"e_1_2_6_11_1","first-page":"11005","volume":"146","author":"Strieth\u2010Kalthoff F.","year":"2024","journal-title":"J. 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