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Crystallographic analysis revealed that these structures and\u00a0\n                    <jats:italic>meta<\/jats:italic>\n                    \u2010benzene have identical geometric properties. Replacement of the central benzene ring in the anticancer drug\n                    <jats:italic>Sonidegib<\/jats:italic>\n                    with 3\u2010oxabicyclo[3.1.1]heptane provided a patent\u2010free analogue with a nanomolar potency, reduced lipophilicity, and improved water solubility (&gt;500%).\n                  <\/jats:p>","DOI":"10.1002\/anie.202505519","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T03:13:12Z","timestamp":1743131592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["3\u2010Oxabicyclo[3.1.1]heptane as an Isostere of\n                    <i>meta<\/i>\n                    \u2010Benzene"],"prefix":"10.1002","volume":"64","author":[{"given":"Dmitry","family":"Dibchak","sequence":"first","affiliation":[{"name":"Enamine Ltd.  Winston Churchill st. 78 Kyiv 02094 Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel K.","family":"Mykhailiuk","sequence":"additional","affiliation":[{"name":"Enamine Ltd.  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