{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:53:19Z","timestamp":1792651999624,"version":"4.5.0"},"reference-count":95,"publisher":"Wiley","issue":"35","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130103"],"award-info":[{"award-number":["82130103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22471063"],"award-info":[{"award-number":["22471063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021173","name":"Central Plains Scholars and Scientists Studio Fund","doi-asserted-by":"publisher","award":["2018002"],"award-info":[{"award-number":["2018002"]}],"id":[{"id":"10.13039\/501100021173","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017699","name":"Henan Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["202103087"],"award-info":[{"award-number":["202103087"]}],"id":[{"id":"10.13039\/501100017699","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021233","name":"Henan Key Laboratory of Organic Functional Molecules and Drug Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021233","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The asymmetric hydrofunctionalization of aliphatic alkenes without auxiliary or stabilizing groups presents a significant challenge in modern organic synthesis. We report herein the nickel\u2010catalyzed enantioselective hydrosilylation of alkyl\u2010substituted\n                    <jats:italic>gem<\/jats:italic>\n                    \u2010difluoroalkenes, which enables the generation of chiral \u03b1\u2010difluoromethylsilanes with excellent regio\u2010 and enantioselectivity. Moreover, the simultaneous construction of carbon\u2010 and silicon\u2010stereogenic centers was achieved with excellent diastereo\u2010 and enantioselectivity using prochiral silanes. This method provides an efficient approach to access sp\n                    <jats:sup>3<\/jats:sup>\n                    \u2010enriched C\u2010stereogenic centers equipped with high\u2010value difluoromethyl groups. The resulting enantioenriched silanes could undergo a range of stereospecific transformations. Density functional theory (DFT) calculations were performed to elucidate the detailed mechanism.\n                  <\/jats:p>","DOI":"10.1002\/anie.202506157","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T10:05:00Z","timestamp":1751537100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Regio\u2010, Diastereo\u2010, and Enantioselective Hydrosilylation of Alkyl\n                    <i>gem<\/i>\n                    \u2010Difluoroalkenes to Construct Carbon and Silicon Stereogenic Centers"],"prefix":"10.1002","volume":"64","author":[{"given":"Huanhuan","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Antiviral Drugs NMPA Key Laboratory for Research and Evaluation of Innovative Drug School of Chemistry and Chemical Engineering Pingyuan Laboratory Henan Normal University  Xinxiang 453007 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology School of Basic Medical Sciences Zhengzhou University  Zhengzhou 450001 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Antiviral Drugs NMPA Key Laboratory for Research and Evaluation of Innovative Drug School of Chemistry and Chemical Engineering Pingyuan Laboratory Henan Normal University  Xinxiang 453007 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Antiviral Drugs NMPA Key Laboratory for Research and Evaluation of Innovative Drug School of Chemistry and Chemical Engineering Pingyuan Laboratory Henan Normal University  Xinxiang 453007 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Antiviral Drugs NMPA Key Laboratory for Research and Evaluation of Innovative Drug School of Chemistry and Chemical Engineering Pingyuan Laboratory Henan Normal University  Xinxiang 453007 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbiao","family":"Chang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Antiviral Drugs NMPA Key Laboratory for Research and Evaluation of Innovative Drug School of Chemistry and Chemical Engineering Pingyuan Laboratory Henan Normal University  Xinxiang 453007 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7342-2966","authenticated-orcid":false,"given":"Dachang","family":"Bai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Antiviral Drugs NMPA Key Laboratory for Research and Evaluation of Innovative Drug School of Chemistry and Chemical Engineering Pingyuan Laboratory Henan Normal University  Xinxiang 453007 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00334"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-018-0001-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.201800314"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00164"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00628"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c13482"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202304882"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00972B"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00713"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.3c01221"},{"key":"e_1_2_7_11_1","first-page":"7566","volume":"53","author":"Chen J. P.","year":"2024","journal-title":"Chem. Rev."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.024.202303678"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201507151"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b12307"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7QO00613F"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.1c00212"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202100763"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00426C"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c05251"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.checat.2022.10.020"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b09346"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c04043"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202300529"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00167"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b05149"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c02753"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-023-01037-9"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c01040"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c12881"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/B711844A"},{"key":"e_1_2_7_31_1","first-page":"1785","volume":"31","author":"Wang J.","year":"2011","journal-title":"Chin. J. Org. Chem."},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10108"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01788"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr030143e"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar500282z"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr500277b"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202112251"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201706631"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10851-4"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-019-0289-7"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201903954"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2399-1"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c04462"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26667-0"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202101076"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c06432"},{"key":"e_1_2_7_47_1","first-page":"11418","volume":"146","author":"Chen F.","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00111a021"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b04457"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200501769"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf8078"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2019.09.012"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c02697"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-024-01253-x"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201813801"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2020.03.031"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c04278"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c04949"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c01680"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202317935"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202406324"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202114918"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1039\/C0CS00037J"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm3010114"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.checat.2022.07.009"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.6023\/cjoc202305001"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.4c00667"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr900359c"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.6b02990"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201605198"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202008729"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11426-022-1480-y"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201411884"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b13029"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b04137"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201807493"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b01638"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201802806"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202100775"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202002289"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202113052"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202214147"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202413753"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202205624"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-55592-1"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50743-w"},{"key":"e_1_2_7_87_1","unstructured":"Deposition number 2424759 (for3e) and 2424760 (for9) contains the supplementary crystallographic data for this paper. These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe Access Structures service."},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201207361"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21489-6"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.02.025"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c03580"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202216878"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0127335"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4020-8172-9"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr00005a013"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202506157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T09:38:26Z","timestamp":1762594706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202506157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":95,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2025,8,25]]}},"alternative-id":["10.1002\/anie.202506157"],"URL":"https:\/\/doi.org\/10.1002\/anie.202506157","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,31]]},"assertion":[{"value":"2025-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202506157"}}