{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:26:08Z","timestamp":1778747168239,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/568\/2022"],"award-info":[{"award-number":["CRG\/568\/2022"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Here, we report a single\u2010crystal\u2010to\u2010single\u2010crystal (SCSC) synthesis of a fully organic ladder polymer via a topochemical azide\u2010alkyne cycloaddition (TAAC) reaction. A designed monomer featuring a rigid benzene core with flexible peptide\u2010linked azide and alkyne groups crystallized with three conformers in the asymmetric unit, as evidenced by the single\u2010crystal X\u2010ray diffraction (SCXRD) analysis. Hydrogen bonding between the amino acid residues facilitates the organization of the monomer in a reactive geometry with inter\u2010conformer azide\u2010alkyne end\u2010to\u2010end distances within Schmidt's criteria. Upon thermal activation, two of the three monomer\u2010conformers reacted to form a dimer, leading to an intermediate 1:1 cocrystal of monomer and dimer. The intermediate cocrystal reacted further, forming a structurally perfect ladder polymer in an SCSC manner. SCXRD analysis confirmed the regiospecificity of the reaction yielding 1,5\u2010triazolyl linkages in both the intermediate dimer and the polymer. The polymerization process was also studied by powder X\u2010ray diffraction (PXRD), differential scanning calorimetry (DSC), and Fourier\u2010transform infrared spectroscopy (FT\u2010IR). This study demonstrates the scope of topochemical polymerization strategies to synthesize architecturally attractive crystalline polymers that enable precise structural elucidation.<\/jats:p>","DOI":"10.1002\/anie.202506699","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T05:55:10Z","timestamp":1746683710000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Single\u2010Crystal\u2010to\u2010Single\u2010Crystal Synthesis of a Rope\u2010Ladder Polymer"],"prefix":"10.1002","volume":"64","author":[{"given":"Haripriya","family":"Balan","sequence":"first","affiliation":[{"name":"School of chemistry Indian Institute of Science Education and Research Thiruvananthapuram, Vithura  Thiruvananthapuram 695551 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopika","family":"Sadasivan","sequence":"additional","affiliation":[{"name":"School of chemistry Indian Institute 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