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While transcytosis\u2010mediated transport offers a promising strategy to overcome biological barriers, existing carriers lack real\u2010time imaging capabilities, particularly in the near\u2010infrared II window, to guide optimization. Herein, we address this dual challenge through a multifunctional poly[L\u2010\u03b3\u2010[2\u2010(\n                    <jats:italic>N<\/jats:italic>\n                    \u2010oxide\u2010\n                    <jats:italic>N,N<\/jats:italic>\n                    \u2010dimethylamino)ethyl]glutamine]\u2010paclitaxel (OPGAX) conjugate integrated with aggregation\u2010induced emission (AIE) luminogens. The OPGAX conjugate self\u2010assembled into uniform nanoparticles (NPs) with a high drug\u2010loading capacity (42.5%) and intense near\u2010Infrared II (NIR\u2010II) fluorescence (1000\u20131350\u00a0nm). The zwitterionic tertiary amine oxide (TAO) moiety endowed OPGAX with protein resistance and cell membrane affinity, leading to prolonged blood circulation and enhanced tumor accumulation. OPGAX NPs performed NIR\u2010II imaging to visualize whole\u2010body vasculature and dynamically track tumor penetration. In 4T1 tumor\u2010bearing mice, OPGAX NPs achieved deep tumor infiltration via transcytosis, visualized dynamically by NIR\u2010II imaging, and suppressed tumor growth. This platform bridges diagnostic certainty with therapeutic efficacy, offering a translatable strategy for image\u2010guided precision oncology.\n                  <\/jats:p>","DOI":"10.1002\/anie.202506770","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T07:14:28Z","timestamp":1757661268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Self\u2010Assembled Nanoconjugates with Aggregation\u2010Induced Emission for Near\u2010Infrared II Imaging and Transcytosis\u2010Driven Cancer Therapy"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9001-9165","authenticated-orcid":false,"given":"Guiping","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Chemistry Department of Chemical and Biological Engineering Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Division of Life Science and State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and Technology  Hong Kong Kowloon 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0732-7669","authenticated-orcid":false,"given":"Wutong","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Chemistry Department of Chemical and Biological Engineering Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Division of Life Science and State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and Technology  Hong Kong Kowloon 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1525-2015","authenticated-orcid":false,"given":"Feiyi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Basic Experiment The Ninth Medical Center of Chinese PLA General Hospital  Beijing 100101 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyang","family":"Dong","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Smart Biomaterials Center for Bionanoengineering Key Laboratory of Biomass Chemical Engineering of the Ministry of Education College of Chemical and Biological Engineering Zhejiang University  Hangzhou 310058 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Department of Chemical and Biological Engineering Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Division of Life Science and State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and Technology  Hong Kong Kowloon 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5893-3407","authenticated-orcid":false,"given":"Yingni","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Department of Chemical and Biological Engineering Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Division of Life Science and State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and Technology  Hong Kong Kowloon 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Department of Chemical and Biological Engineering Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Division of Life Science and State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and Technology  Hong Kong Kowloon 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5754-1703","authenticated-orcid":false,"given":"Jacky W. 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