{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:17:37Z","timestamp":1788959857359,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1509701"],"award-info":[{"award-number":["2024YFA1509701"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22325107"],"award-info":[{"award-number":["22325107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22293011"],"award-info":[{"award-number":["22293011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22171253"],"award-info":[{"award-number":["22171253"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["GG2060000044"],"award-info":[{"award-number":["GG2060000044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A spin\u2010center shift (SCS) is a radical process that commonly involves a 1,2\u2010radical shift along with the elimination of an adjacent leaving group by a two\u2010electron ionic movement. The conventional SCS process is largely limited to 1,2\u2010radical translocation, while a remote SCS event involving 1,\n                    <jats:italic>n<\/jats:italic>\n                    \u2010radical translocation over a greater distance to enable distal bond functionalization remains largely underexplored. Herein, we report the boryl radical\u2010promoted distal deoxygenation and deamination of free benzylic alcohols and simple benzylic amines, respectively, through a remote SCS event. The reaction was initiated by the addition of a 4\u2010dimethylaminopyridine (DMAP)\u2010boryl radical to the carbonyl oxygen atom of a benzoate or benzamide. Then, radical translocation took place across the aromatic ring to promote benzylic C\u2500O or C\u2500N bond cleavage. The resulting radical intermediate subsequently coupled with various alkenes to afford a wide range of alkylated products. The proposed mechanistic pathway was supported by experimental investigations.\n                  <\/jats:p>","DOI":"10.1002\/anie.202506771","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T14:37:33Z","timestamp":1743691053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Remote Spin\u2010Center Shift Enables Activation of Distal Benzylic C\u2500O and C\u2500N Bonds"],"prefix":"10.1002","volume":"64","author":[{"given":"Li\u2010Wen","family":"Hui","sequence":"first","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry Anhui Provincial Key Laboratory of Biomass Chemistry Department of Chemistry University of Science and Technology of China  96 Jinzhai Road Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee Lin","family":"Phang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry Anhui Provincial Key Laboratory of Biomass Chemistry Department of Chemistry University of Science and Technology of China  96 Jinzhai Road Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Yang","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry Anhui Provincial Key Laboratory of Biomass Chemistry Department of Chemistry University of Science and Technology of China  96 Jinzhai Road Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Yu","family":"Lai","sequence":"additional","affiliation":[{"name":"Institute of Advanced Technology University of Science and Technology of China  96 Jinzhai Road Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Lian","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry Anhui Provincial Key Laboratory of Biomass Chemistry Department of Chemistry University of Science and Technology of China  96 Jinzhai Road Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Fu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry Anhui Provincial Key Laboratory of Biomass Chemistry Department of Chemistry University of Science and Technology of China  96 Jinzhai Road Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision and Intelligent Chemistry Anhui Provincial Key Laboratory of Biomass Chemistry Department of Chemistry University of Science and Technology of China  96 Jinzhai Road Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200600915"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.2c00051"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsorginorgau.2c00032"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b12768"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/(SICI)1521-3773(19990301)38:5<643::AID-ANIE643>3.0.CO;2-G","volume":"38","author":"Henkel T.","journal-title":"Angew. Chem. Int. Ed."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.8b01022"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00811"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781420007282"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202200330"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01030"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2020-8923"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41061-022-00381-x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.4c03560"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.20.119"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c09779"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1848-3005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202200769"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c11857"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c12463"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.9b03150"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.organomet.8b00285"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC08387D"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3ra40343b"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14885"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax9955"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201914242"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b13975"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c05993"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.3c00521"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.202201234"},{"key":"e_1_2_6_31_1","author":"Taskinen E. K.","year":"2024","journal-title":"Chem.\u2010Eur. J."},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201901168"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2024.08.002"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC06904F"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.1c04008"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201007571"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg0781"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c05798"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202100784"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202201329"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00752"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b09288"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.8b03112"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.202000147"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.9b03420"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201001440"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201702469"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/a804291h"},{"key":"e_1_2_6_49_1","author":"Zhang F.","year":"2024","journal-title":"Chem.\u2010Eur. J."},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja300416f"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CC06031E"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo101301d"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.1c02729"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja107511g"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b11366"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.2c03085"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2023.129430"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC03283J"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201805961"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c12043"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2005.09.145"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202506771","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202506771","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202506771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T07:59:45Z","timestamp":1770191985000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202506771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,14]]},"references-count":61,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2025,6,10]]}},"alternative-id":["10.1002\/anie.202506771"],"URL":"https:\/\/doi.org\/10.1002\/anie.202506771","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,14]]},"assertion":[{"value":"2025-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202506771"}}