{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T20:34:41Z","timestamp":1787690081765,"version":"build-2784847793"},"reference-count":87,"publisher":"Wiley","issue":"28","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52473314"],"award-info":[{"award-number":["52473314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52173177"],"award-info":[{"award-number":["52173177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["5237300"],"award-info":[{"award-number":["5237300"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20230010"],"award-info":[{"award-number":["BK20230010"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20221362"],"award-info":[{"award-number":["BK20221362"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20240830"],"award-info":[{"award-number":["BK20240830"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20220634"],"award-info":[{"award-number":["BK20220634"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Organic cocrystals, particularly the evolution from binary to higher\u2010order structures, have garnered considerable attention due to their tunable intermolecular interactions and unique material properties. Binary cocrystals, formed through \u03c0\u2010\u03c0 stacking, charge transfer, and hydrogen\/halogen bonding, allow for precise control over molecular packing and enhanced optoelectronic properties. In contrast, higher\u2010order cocrystals, incorporating three or more components, enable greater complexity and functional diversity. Strategies such as homologation via isostructural substitution, hierarchical intermolecular interactions, and long\u2010range Synthon Aufbau Modules facilitate the synthesis of these advanced materials. The shift toward higher\u2010order cocrystals paves the way for novel applications in fields such as deep learning for cocrystal prediction, drug design, organic solar cells, and NIR\u2010II photothermal conversion. However, challenges related to molecular screening, ratio optimization, scalable synthesis, and long\u2010term stability remain critical hurdles for the broader implementation of these materials in practical applications.<\/jats:p>","DOI":"10.1002\/anie.202507102","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T10:23:50Z","timestamp":1749119030000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["From Binary to Higher\u2010Order Organic Cocrystals: Design Principles and Performance Optimization"],"prefix":"10.1002","volume":"64","author":[{"given":"Jia\u2010Hao","family":"Jiang","sequence":"first","affiliation":[{"name":"School of Chemistry and Life Sciences Suzhou University of Science and Technology  Suzhou Jiangsu 215009 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Functional Nano &amp; Soft Materials (FUNSOM) Soochow University  Suzhou Jiangsu 215123 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Chemistry and Life Sciences Suzhou University of Science and Technology  Suzhou Jiangsu 215009 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0935-0835","authenticated-orcid":false,"given":"Xue\u2010Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Functional Nano &amp; Soft Materials (FUNSOM) Soochow University  Suzhou Jiangsu 215123 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46788-6"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c11425"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18431-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24381-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202215836"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202105405"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c02061"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c00648"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01364-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201806149"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52187-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/b708112j"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/b313552g"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/b315687g"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC06475A"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2052252515023957"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2052252515023945"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c10183"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304225"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b12501"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201904339"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/b505883j"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/cg060516f"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cs60014a"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b02435"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b02854"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.5b00957"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.5b00628"},{"key":"e_1_2_8_29_1","first-page":"12921","volume":"24","author":"Jiang J.\u2010H.","year":"2024","journal-title":"Nano Lett."},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20010903)40:17<3240::AID-ANIE3240>3.0.CO;2-X"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc43822h"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3ce40729b"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2052252516000543"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC08135B"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202101248"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c09732"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202302751"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/b822963p"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c00135"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00124"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5SC02913A"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.03.003"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CE00395E"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.7b01375"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202008214"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b12501"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00211"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CE00098B"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211160"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2020.10.007"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202413805"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11731-7"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC04758A"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-821978-2.00076-3"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.26068"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/B818330A"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.22885"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202402175"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.2c00184"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.4c01695"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/cg034098f"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201204604"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201204604"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar5001555"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202103516"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202408053"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.2c01094"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.1c00303"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202412712"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1039\/b106584j"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2052252513024421"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.200700343"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3sc51073e"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26226-7"},{"key":"e_1_2_8_74_1","first-page":"8704","volume":"24","author":"Guo J.","year":"2024","journal-title":"Cryst. Growth Des."},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0337-2"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa8415"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CE00587C"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.9b00318"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.0c00767"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25978"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat2663"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14539"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202009467"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201300623"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-019-0093-4"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-023-00545-1"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202507102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:24:21Z","timestamp":1767626661000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202507102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,16]]},"references-count":87,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2025,7,7]]}},"alternative-id":["10.1002\/anie.202507102"],"URL":"https:\/\/doi.org\/10.1002\/anie.202507102","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,16]]},"assertion":[{"value":"2025-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202507102"}}