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Despite extensive efforts, current chemicals for biofilm eradication remain insufficient, with the reliance on single\u2010structure antimicrobials further exacerbating resistance. Photoisomerizable spiropyran derivatives reversibly transition between conformational states, alternately exerting antimicrobial activity against pathogens and potentially mitigating resistance. However, the biofilm\u2010eradicating potential of spiropyran derivatives remains unverified, while their application is hindered by limited fatigue resistance, suboptimal foliar affinity, and reliance on UV\u2010induced isomerization, all of which are incompatible with sustainable agriculture. Herein, we present a supramolecular strategy to fabricate\n                    <jats:bold>SpA6<\/jats:bold>\n                    (MC)\u2282CB[8], a self\u2010assembled complex of the spiropyran derivative\n                    <jats:bold>SpA6<\/jats:bold>\n                    and cucurbit[8]uril, offering day\u2013night cycle isomerization, enhanced photostability, potent biofilm disruption, improved foliar adhesion, and high antibacterial activity. Notably, neither ambient light nor darkness attenuates its potency, enabling persistent antibacterial activity across diverse molecular configurations. In vivo studies demonstrate its superior dual protective\/curative efficacy (54.73%\/49.60%) at 200 \u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    against bacterial leaf blight, surpassing thiazole copper (37.63%\/33.58%) and bismerthiazol (31.20%\/25.59%) without compromising safety, while extended indications reveal its enhanced efficacy (78.99%\/63.50%) against citrus canker, outperforming thiazole copper (59.50%\/41.42%). This work establishes a paradigm for developing light\u2010responsive supramolecular agrochemicals that combine structural dynamism with enhanced functionality, offering sustainable solutions against plant pathogens.\n                  <\/jats:p>","DOI":"10.1002\/anie.202507179","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T13:40:12Z","timestamp":1753450812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["From Spiropyran to a Circadian\u2010Responsive Photochromic Supramolecular System for Sustainable Crop Protection: Enhanced Photostability, Biofilm Disintegration, and Foliar Adhesion"],"prefix":"10.1002","volume":"64","author":[{"given":"Lijun","family":"Fan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center for Research and Development of Fine Chemicals of Guizhou University  Guiyang 550025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kongjun","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center for Research and Development of Fine Chemicals of Guizhou University  Guiyang 550025 China"},{"name":"Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi Medical University  Zunyi 563000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghan","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center for Research and Development of Fine Chemicals of Guizhou University  Guiyang 550025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. M. W. W.","family":"Kandegama","sequence":"additional","affiliation":[{"name":"Department of Horticulture and Landscape Gardening, Faculty of Agriculture and Plantation Management Wayamba University of Sri Lanka  Makandura Gonawila (NWP) 60170 Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9904-0664","authenticated-orcid":false,"given":"Peiyi","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center for Research and Development of Fine Chemicals of Guizhou University  Guiyang 550025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2021.03.002"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c16026"},{"key":"e_1_2_8_3_1","volume":"12","author":"He X.","year":"2025","journal-title":"Adv. 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