{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:03:52Z","timestamp":1792652632704,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Piezocatalytic\u00a0therapy is a novel therapeutic strategy that uses mechanical energy to drive catalytic reactions to generate cytotoxic reactive oxygen species (ROS). However, existing materials are limited by low intrinsic catalytic efficiency and a single route to ROS production. This makes it difficult to break through the antioxidant barrier of the tumor microenvironment, which severely limits the antitumor efficacy. Herein, we synthesized sulfur vacancy (S\n                    <jats:sub>v<\/jats:sub>\n                    )\u2010engineered ZnIn\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>4<\/jats:sub>\n                    nanosheets (ZIS\u20102\/4\/8) by adjusting the concentrations of sulfur source thioacetamide (TAA). The increase in S\n                    <jats:sub>v<\/jats:sub>\n                    concentration simultaneously achieved the optimization of the energy band structure and the enhancement of the piezoelectric performance (\n                    <jats:italic>d<\/jats:italic>\n                    <jats:sub>33<\/jats:sub>\n                    from 21.6 to 46.7\u00a0mV V\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). Under US irradiation, S\n                    <jats:sub>v<\/jats:sub>\n                    \u2010ZnIn\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>4<\/jats:sub>\n                    can efficiently generate ROS storms via multiple pathways, including \u2022O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    ,\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , \u2022OH, and H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , which overcome the limitations of the tumor microenvironment and achieved effective tumor cell killing. In addition, the ROS storm induced by the ultrasound (US) can also initiate immunogenic cell death (ICD), promoting dendritic cells (DCs) maturation and CD8\u207a T cells infiltration. This multi\u2010pathway ROS burst strategy not only breaks through tumor antioxidant defenses but also induces ICD to form a cascade of immune responses. This demonstrates the advantages of combining piezocatalytic and immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/anie.202507502","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T04:45:10Z","timestamp":1749530710000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Multipath ROS Storm and Immune Activation via\u00a0Sulfur Vacancy\u2010Optimized ZnIn\n                    <sub>2<\/sub>\n                    S\n                    <sub>4<\/sub>\n                    \u00a0Nanosheets for Piezocatalytic Tumor Therapy"],"prefix":"10.1002","volume":"64","author":[{"given":"Mingkai","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P.R. China"},{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China  Hefei 230026 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3717-857X","authenticated-orcid":false,"given":"Binbin","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P.R. China"},{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China  Hefei 230026 P.R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sainan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhendong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Tan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P.R. China"},{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China  Hefei 230026 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P.R. China"},{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China  Hefei 230026 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials &amp; Surface Technology of Ministry of Education, College of Material Sciences and Chemical Engineering Harbin Engineering University  Harbin 150001 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping'an","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P.R. China"},{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China  Hefei 230026 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9572-2134","authenticated-orcid":false,"given":"Jun","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P.R. China"},{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China  Hefei 230026 P.R. China"},{"name":"Key Laboratory of Superlight Materials &amp; Surface Technology of Ministry of Education, College of Material Sciences and Chemical Engineering Harbin Engineering University  Harbin 150001 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202416426"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00648F"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202409663"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c04385"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202401758"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202412069"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202317218"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202414879"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c01856"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1MH01899J"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202308726"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c05103"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202500406"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c09834"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.216282"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202208256"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2024.110346"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202202180"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2019.01.095"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20230133"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20230134"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202303586"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00844G"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2020.119250"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2022.107919"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2025.102666"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.4c01656"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2024.10.108"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmst.2020.09.045"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b02290"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c10390"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202209446"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.4c05717"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202100887"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2022.214898"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202403228"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202415485"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301152"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202302964"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201302685"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40843-024-2844-8"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202405741"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24511-z"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202314780"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202421402"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.4c00843"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.109856"}],"container-title":["Angewandte 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