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Developing a comprehensive strategy integrating antibiosis and anti\u2010inflammation to promote revascularization and accelerate wound healing is highly desirable. Nevertheless, current therapeutic methods still face two major challenges: 1) how to combat bacterial drug resistance, 2) how to achieve spatiotemporal control over bacterial elimination and inflammation reduction. To address these issues, a novel H\n                    <jats:sub>2<\/jats:sub>\n                    S donor functionalized molecular machine (MM), ACR\u2010DM\u2010HS, was developed. It selectively binds to and disturbs the bacterial membrane through a light\u2010active vibronic\u2010driven mechanochemical action (VDA), which synergizes with photodynamic therapy (PDT) to efficiently eradicate multidrug\u2010resistant bacteria and biofilms, and conquers the evolution of bacterial resistance. Furthermore, it releases H\n                    <jats:sub>2<\/jats:sub>\n                    S in infected tissues to scavenge excess reactive oxygen species (ROS), inhibit the secretion of inflammatory factors, promote angiogenesis, and accelerate the healing of diabetic wounds in vivo. This work provides an integrated strategy combining antibiotics and anti\u2010inflammation to treat with multidrug resistance bacterial\u2010infected chronic wounds.\n                  <\/jats:p>","DOI":"10.1002\/anie.202507833","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T23:49:11Z","timestamp":1747352951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["H\n                    <sub>2<\/sub>\n                    S Donor Functionalized Molecular Machine for Combating Multidrug\u2010Resistant Bacteria Infected Chronic Wounds"],"prefix":"10.1002","volume":"64","author":[{"given":"Yuan","family":"Chen","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering Sichuan University Chengdu 610065 P.R. China"},{"name":"School of Life Science and Engineering Southwest Jiaotong University Chengdu 610031 P.R. 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