{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:41:27Z","timestamp":1790869287874,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22375223"],"award-info":[{"award-number":["22375223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22075321"],"award-info":[{"award-number":["22075321"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Organic hydroxylamines, pivotal intermediates in pharmaceutical and polymer chemistry, face persistent challenges in selective synthesis. Its main difficulty lies in the strong repulsion between the lone pair electrons on the N and O atoms, which makes their N\u2500O bond easy to break, leading to a over\u2010reduction to amine compounds. Here, we present a green electrocatalytic strategy for the first time that converts oximes to hydroxylamines over CuS. Specially,\n                    <jats:italic>N<\/jats:italic>\n                    \u2010benzylhydroxylamine was achieved with 95% conversion and 80% selectivity from benzaldoxime at \u22120.9\u00a0V versus reversible hydrogen electrode. Mechanistic investigations reveal that CuS can optimize the adsorption energy of the reaction intermediates, making the N\u2500O bond more difficult to cleave during the electrocatalytic hydrogenation, thus leading to a high selectivity formation of hydroxylamines. This methodology is successfully extended to other hydroxylamines and further enables the unprecedented synthesis of organic hydroxylamines from nitric oxide gas. Our work establishes a sustainable electrosynthetic platform for hydroxylamines synthesis without organic solvents and additional reduction agents, providing new insights for modern green chemical synthesis.\n                  <\/jats:p>","DOI":"10.1002\/anie.202507853","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T09:58:57Z","timestamp":1746784737000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Green Electrosynthesis of Hydroxylamines via CuS Suppressing N\u2500O Bond Cleavage"],"prefix":"10.1002","volume":"64","author":[{"given":"Suisheng","family":"Li","sequence":"first","affiliation":[{"name":"MOE Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular Engineering Lehn Institute of Functional Materials School of Chemistry Sun Yat\u2010Sen University  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peisen","family":"Liao","sequence":"additional","affiliation":[{"name":"MOE Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular Engineering Lehn Institute of Functional Materials School of Chemistry Sun Yat\u2010Sen University  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Li","sequence":"additional","affiliation":[{"name":"MOE Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular Engineering Lehn Institute of Functional Materials School of Chemistry Sun Yat\u2010Sen University  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Jiang","sequence":"additional","affiliation":[{"name":"MOE Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular Engineering Lehn Institute of Functional Materials School of Chemistry Sun Yat\u2010Sen University  Guangzhou 510006 China"},{"name":"BYD Auto Industry Company Limited  Shenzhen 518083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runan","family":"Xiang","sequence":"additional","affiliation":[{"name":"MOE Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular Engineering Lehn Institute of Functional Materials School of Chemistry Sun Yat\u2010Sen University  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangqin","family":"Li","sequence":"additional","affiliation":[{"name":"MOE Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular Engineering Lehn Institute of Functional Materials School of Chemistry Sun Yat\u2010Sen University  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408448509023765"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.0c03808"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf8713"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.3c00238"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.202000704"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202103683"},{"key":"e_1_2_7_7_1","author":"Chen J.","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-022-00971-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.ado4936"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01209-x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb2559"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c07506"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c12479"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00741a013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49138-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41893-021-00682-x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202407287"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202401163"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3QI00885A"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CP02199G"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2022.118423"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-016-1021-1"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c02755"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-20956-4"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-56101-8"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esci.2023.100156"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202407392"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44160-024-00522-8"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.checat.2022.06.002"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00158"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41893-024-01330-w"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41863-w"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fmre.2022.07.014"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307913"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esci.2023.100156"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.26599\/NR.2025.94907038"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202411539"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2022.108056"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202401221"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202312746"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.110005"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-018-0201-x"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202002124"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11426-024-2307-y"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2QO00670G"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3GC00124E"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-022-00882-4"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37821-1"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-023-00923-6"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2423542122"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c00294"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10800-020-01428-x"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202417130"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC07208J"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TA09264B"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c00075"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202004533"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202423861"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/celc.201900066"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.3c00417"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/catal12101135"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57573-4"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30291-x"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202507853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T18:19:00Z","timestamp":1764440340000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202507853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":63,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2025,7,14]]}},"alternative-id":["10.1002\/anie.202507853"],"URL":"https:\/\/doi.org\/10.1002\/anie.202507853","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,19]]},"assertion":[{"value":"2025-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202507853"}}