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UV\u2013vis, circular dichroism, and NMR spectroscopies, alongside X\u2010ray crystallographic and DFT computational studies are used to unambiguously characterize a highly reversible stepwise photochemical transformation to an all\u2010\n                    <jats:italic>cis<\/jats:italic>\n                    state in which structural integrity and optical purity have been retained. Although the all\u2010\n                    <jats:italic>trans<\/jats:italic>\n                    state of the water\u2010soluble enantiomers exhibited low or moderate activity against Gram\u2010positive strains, irradiation at 365\u00a0nm led to up to eight\u2010fold reduction in MIC. 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