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Although the development of new PSs through organic synthesis has been a focus of active research, supramolecular chemistry offers a complementary pathway. This study presents a versatile supramolecular strategy to convert conventional fluorophores into heavy\u2010atom\u2010free PSs using a cyclic peptide\u2010based scaffold that densely assembles fluorophore moieties. Results demonstrate that supramolecular PSs constructed from four synthetic fluorophore types\u2014cyanines, coumarins, rhodamines, and BODIPYs\u2014exhibit a remarkable enhancement in ROS generation efficiency, attributed to the increased intersystem crossing efficiency induced by self\u2010assembly. Moreover, these supramolecular PSs function as visible\u2010light photocatalysts, efficiently regenerating NAD\n                    <jats:sup>+<\/jats:sup>\n                    from NADH. The densely packed polymer shell further shields enzymes from ROS\u2010induced deactivation, thereby facilitating the development of robust photoenzyme catalytic systems. This study not only enriches the design methodology of heavy\u2010atom\u2010free PSs, but also paves the way for eco\u2010friendly photobiocatalytic systems.\n                  <\/jats:p>","DOI":"10.1002\/anie.202508968","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T22:16:03Z","timestamp":1747088163000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Heavy\u2010Atom\u2010Free Supramolecular Photosensitizers Derived from Conventional Fluorophores"],"prefix":"10.1002","volume":"64","author":[{"given":"Lingfeng","family":"Fan","sequence":"first","affiliation":[{"name":"Shenzhen Grubbs Institute Southern University of Science and Technology  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wu","sequence":"additional","affiliation":[{"name":"Shenzhen Grubbs Institute Southern University of Science and Technology  Shenzhen 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